1321985-62-9

Upstream product

• 558-13-4 carbon tetrabromide 
• 90-60-8 3,5-dichlorosalicyclaldehyde 

Downstream Products

• 18761-38-1 5,7-dichloro-2-phenylbenzo[b]furan 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 2050-68-2 4,4'-dichlorobiphenyl 
• 1374787-37-7 5,7-dichloro-2-(4-chlorophenyl)benzofuran 
• 398-23-2 4,4'-difluorobiphenyl 
• 1374787-38-8 5,7-dichloro-2-(4-fluorophenyl)benzofuran 
• 92-52-4 biphenyl 
• 551001-83-3 5,7-Dichloro-2-(4-methoxy-phenyl)-benzofuran 
• 42969-85-7 5,7-dichloro-2-methylbenzofuran 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of 1-(2-benzofuryl)-N-heteroarenes fromo-hydroxy-gem-(dibromovinyl)benzenes and N-heteroarenes

An efficient method for the synthesis of 1-(2-benzofuryl)-N-heteroarenes is developed fromo-hydroxy-gem-(dibromovinyl)benzenes and N-heteroarenes under copper-catalyzed tandem reaction conditions. This methodology displayed a broad substrate scope and high yields in the preparation of a variety of 1-(2-benzofuryl)-N-heteroarenes. Further, 1-(2-benzofuryl)-N-heteroarenes were also applied in the synthesis of polycyclic benzofuro-indolo-pyridine scaffolds under palladium-catalyzed dehydrogenative coupling conditions. Overall, the present tandem approach is general, synthetically advantageous and avoids air-sensitive reagents.

Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents

A highly efficient and simple route for the synthesis of 2-substituted benzo[ b ]furans has been developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b ]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl-substituted benzo[ b ]furan derivatives can be obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls bearing electron-donating or electron-withdrawing groups in 2-halobenzo[ b ]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b ]furans as well, and three bioactive molecules with 2-substituted benzo[ b ]furan skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale make this protocol a potentially practical method to synthesize 2-substituted benzo[ b ]furan derivatives. On the basis of the experimental results, a possible catalytic cycle has been proposed.