132213-03-7

Basic information

• Product Name: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE
• Synonyms: IMidazo[1,2-a]pyridine-6-MethanaMine;C-Imidazo[1,2-a]pyridin-6-yl-methylamine;6-(Aminomethyl)imidazo[1,2-a]pyridine97%;IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE;6-(Aminomethyl)imidazo[1,2-a]pyridine;6-(Aminomethyl)imidazo[1,2-a]pyridine 97%;iMidazo[1,2-a]pyridin-6-ylMethanaMine;(H-iMidazo[1,2-a]pyridin-6-yl)MethanaMine
• CAS NO: 132213-03-7
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• EINECS: 200-589-5
• Mol File: 132213-03-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 96.5-99
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.26g/cm³
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 7.84±0.29(Predicted)
• CAS DataBase Reference: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(132213-03-7)
• EPA Substance Registry System: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(132213-03-7)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22
• Hazardous Substances Data: 132213-03-7(Hazardous Substances Data)

Usage

General Description

IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE, also known as IPAM, is a chemical compound with the molecular formula C9H10N4. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. IPAM has a heterocyclic structure containing an imidazole ring fused to a pyridine ring, with a methylamine group attached to the sixth carbon of the pyridine ring. It is a versatile building block in organic chemistry and can undergo various reactions to form a wide range of derivative compounds. IPAM is a valuable tool for medicinal chemists and drug discovery researchers due to its potential for creating novel bioactive molecules. It is also used in the synthesis of ligands for metal-catalyzed cross-coupling reactions and as a precursor in the preparation of functionalized heterocycles.

InChI:InChI=1/C8H9N3/c9-5-7-1-2-8-10-3-4-11(8)6-7/h1-4,6H,5,9H2

Upstream product

• 106850-34-4 imidazo[1,2-a]pyridine-6-carbonitrile 
• 4214-73-7 6-aminonicotinonitrile 
• 113293-71-3 (6-amino-3-pyridinyl)methanol 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 329-89-5 6-aminonicotinic amide 
• 132213-07-1 6-(hydroxymethyl)imidazo[1,2-a]pyridine 

Downstream Products

• 1313723-21-5 6-(4-fluorophenyl)-1-(imidazo[1,2-a]pyridin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 
• 1363133-95-2 1-[4-(benzenesulfonyl)phenyl]-3-{imidazo[1,2-a]pyridin-6-ylmethyl}urea 

Relevant articles and documents

MASP-2 INHIBITORS AND METHODS OF USE

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

The photosolvolysis of N-arylmethyladenines. Photoremovable N-arylmethyl protective groups for N-containing compounds

N-arylmethyladenines are photolyzed in water, giving adenine and the corresponding arylmethanols.The reaction is not only observed when the arylmethyl group is a metasubstituted benzyl, but also with more complex substituents like imidazopyridin-6-ylmethyl.Meta-substituted arylmethyl groups are proposed as photoremovable N-protective groups in adenine chemistry.