132213-03-7

Basic information

• Product Name: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE
• Synonyms: IMidazo[1,2-a]pyridine-6-MethanaMine;C-Imidazo[1,2-a]pyridin-6-yl-methylamine;6-(Aminomethyl)imidazo[1,2-a]pyridine97%;IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE;6-(Aminomethyl)imidazo[1,2-a]pyridine;6-(Aminomethyl)imidazo[1,2-a]pyridine 97%;iMidazo[1,2-a]pyridin-6-ylMethanaMine;(H-iMidazo[1,2-a]pyridin-6-yl)MethanaMine
• CAS NO: 132213-03-7
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• EINECS: 200-589-5
• Mol File: 132213-03-7.mol

Chemical Properties

• Melting Point: 96.5-99
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.26g/cm³
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 7.84±0.29(Predicted)
• CAS DataBase Reference: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(132213-03-7)
• EPA Substance Registry System: IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE(132213-03-7)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22
• Hazardous Substances Data: 132213-03-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE is used as an intermediate for the synthesis of various pharmaceuticals. Its heterocyclic structure and ability to undergo various reactions make it a promising candidate for creating novel bioactive molecules, contributing to the development of new drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE is used as an intermediate for the synthesis of agrochemicals. Its versatility in organic chemistry allows for the development of new compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Organic Chemistry:
IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE is used as a versatile building block in organic chemistry. Its ability to form a wide range of derivative compounds makes it a valuable tool for researchers in the field, enabling the exploration of new chemical reactions and the synthesis of innovative organic compounds.
Used in Ligand Synthesis for Metal-Catalyzed Cross-Coupling Reactions:
IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE is used as a precursor in the preparation of ligands for metal-catalyzed cross-coupling reactions. Its unique structure and reactivity make it suitable for the development of new ligands that can improve the efficiency and selectivity of these reactions, which are widely used in the synthesis of complex organic molecules.
Used in the Preparation of Functionalized Heterocycles:
In the field of heterocyclic chemistry, IMIDAZO[1,2-A]PYRIDIN-6-YLMETHYLAMINE is used as a precursor for the synthesis of functionalized heterocycles. Its heterocyclic structure and the presence of a methylamine group make it an ideal starting material for the development of new heterocycles with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C8H9N3/c9-5-7-1-2-8-10-3-4-11(8)6-7/h1-4,6H,5,9H2

Upstream product

• 132213-07-1 6-(hydroxymethyl)imidazo[1,2-a]pyridine 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 113293-71-3 (6-amino-3-pyridinyl)methanol 
• 4214-73-7 6-aminonicotinonitrile 
• 106850-34-4 imidazo[1,2-a]pyridine-6-carbonitrile 
• 329-89-5 6-aminonicotinic amide 

Downstream Products

• 1363133-95-2 1-[4-(benzenesulfonyl)phenyl]-3-{imidazo[1,2-a]pyridin-6-ylmethyl}urea 
• 1313723-21-5 6-(4-fluorophenyl)-1-(imidazo[1,2-a]pyridin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 

Relevant articles and documents

MASP-2 INHIBITORS AND METHODS OF USE

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the N- oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, formula (I) wherein A, R1, R2, R3, R3', R4, R4', X, Y, Z, T are as defined in the claims. The invention further relates to an in vitro method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, inflammatory disorders, cardiovascular diseases, viral induced diseases, circulatory diseases, fibro-proliferative diseases and pain sensitization disorders.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

The photosolvolysis of N-arylmethyladenines. Photoremovable N-arylmethyl protective groups for N-containing compounds

N-arylmethyladenines are photolyzed in water, giving adenine and the corresponding arylmethanols.The reaction is not only observed when the arylmethyl group is a metasubstituted benzyl, but also with more complex substituents like imidazopyridin-6-ylmethyl.Meta-substituted arylmethyl groups are proposed as photoremovable N-protective groups in adenine chemistry.