132235-41-7

Basic information

• Product Name: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide
• Synonyms: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide
• CAS NO: 132235-41-7
• Molecular Weight: 326.48
• Mol File: 132235-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide(132235-41-7)
• EPA Substance Registry System: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide(132235-41-7)

Safety Data

• Hazardous Substances Data: 132235-41-7(Hazardous Substances Data)

Upstream product

• 2216-51-5 (-)-menthol 
• 55386-67-9 2-methyl-3,4,5,6-tetrahydropyridine-1-oxide 
• 26127-08-2 (1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane 
• 132235-37-1 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 

Downstream Products

• 89115-95-7 (S)-2-Methyl-2-piperidinecarboxylic acid 
• 132235-44-0 (2S)-2-methyl-2-piperidinecarboxamide 

Relevant articles and documents

Preparation and Use of Chloromethyl (-)-Menthyl Ether in the Synthesis of Optically Pure α-Branched α-Amino Nitriles

The synthesis of optically pure chloromethyl (-)-menthyl ether (2b) and its use in the synthesis of di-(-)-menthyl acetal (-)-menthyl (+)-menthyl acetals are described.The diastereomeric mixed acetals 7a,b and 8a,b are easily obtainable from the nitrones 5 and 6, KCN and 2b.The mixture of diastereomers are separated into the pure components 7a, 7b and 8a, 8b by simple silica gel column chromatography.Hydrolysis of these products (H2O2/Na2CO3, ultrasound) followed by N-O cleavage affords the heterocyclic α-methyl-α-amino amides 11a, 11b and 12a, 12b.These are subsequently hydrolyzed to give the corresponding α-methyl-α-amino acids with S and R configuration, respectively.