132281-35-7Relevant academic research and scientific papers
Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
Adeyemi, Christiana M.,Hoppe, Heinrich C.,Isaacs, Michelle,Klein, Rosalyn,Lobb, Kevin A.,Kaye, Perry T.
, p. 2371 - 2378 (2019/03/23)
An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
Convenient Method for Preparation of Dialkylphosphoramidopropionic Acids and Esters
Kerdel, Katia,Baboulene, Michel,Lattes, Armand
, p. 2775 - 2784 (2007/10/02)
Silylation at the alpha position of N-propargyl dialkylphosphoramidates enables preparation of dialkylphosphoramido propionic acids in 50-60percent yield after hydroboration/oxidation.Treatment with Amberlyst 15 resin in the presence of methanol leads to
