132283-66-0

Basic information

• Product Name: (3R,10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline
• Synonyms: (3R,10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline
• CAS NO: 132283-66-0
• Molecular Weight: 251.328
• Mol File: 132283-66-0.mol

Chemical Properties

• CAS DataBase Reference: (3R,10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline(132283-66-0)
• EPA Substance Registry System: (3R,10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline(132283-66-0)

Safety Data

• Hazardous Substances Data: 132283-66-0(Hazardous Substances Data)

Upstream product

• 28272-96-0 2-vinylbenzaldehyde 
• 56613-80-0 D-2-phenylglycinol 
• 132283-65-9 (1'R)-2-(2-hydroxy-1-phenylethyl)-3,4-dihydroisoquinolinium bromide 
• 22901-09-3 2-(2-bromoethyl)benzaldehyde 

Downstream Products

• 132283-72-8 (1S,1'R)-2-(2-hydroxy-1-phenylethyl)-1-phenethyl-1,2,3,4-tetrahydroisoquinoline 
• 132283-71-7 (1S,1'R)-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 132283-70-6 (1S,1'R)-1-butyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 132302-54-6 (1R,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 132302-54-6 (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 156545-86-7 (1R,1'R)-2-(2-hydroxy-1-phenylethyl)-1-methoxycarbonylmethyl-1,2,3,4-tetrahydroisoquinoline 
• 84010-75-3 (S)-1-β-phenylethyl-1,2,3,4-tetrahydro-isoquinoline 
• 57680-86-1 (1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 22990-19-8 (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 132283-69-3 (1R,1'R)-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 132283-69-3 (1S,1'R)-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

An efficient method for construction of tetrahydroisoquinoline skeleton via double cyclization process using ortho-vinylbenzaldehydes and amino alcohols: application to the synthesis of (S)-cryptostyline II

Thermal double cyclization reaction using ortho-vinylbenzaldehyde and 3-aminopropanols proceeded smoothly to give isoquinoline derivatives via 6π-azaelectrocyclization pathway. The method was applied to the efficient synthesis of (S)-cryptostyline II.

on Water C(sp3)-H Functionalization/C-O/C-N Bonds Formations: Synthesis of Functionalized Oxazolidines and Imidazolidines

On water oxidative C(sp3)-H functionalization/C-O/C-N bonds formations using tetrabutylammonium iodide as the catalyst and tert-butyl hydroperoxide in water (T-Hydro) as the oxidant affords a potential route for the construction of functionalized oxazolidines and imidazolidines. The reaction is simple, regioselective, and effective at moderate temperature with broad substrate scope. In the case of optically active substrates, the oxidative cyclization can be accomplished with high optical purities.