13229-35-1

Upstream product

• 1197-22-4 N-phenylmethanesulfonamide 
• 74-88-4 methyl iodide 
• 54769-22-1 1-methanesulfonyloxy-1,2,3-benzotriazole 
• 100-61-8 N-methylaniline 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 87712-30-9 ethylcarboxy-N-methyl-N-phenyl-1-methanesulfonamide 
• 61738-44-1 N-methyl-C,N-diphenyl-methanesulfonamide 
• 845280-49-1 C₁₅H₁₄FNO₃S 
• 92-52-4 biphenyl 

Relevant academic research and scientific papers

A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives

(Chemical Equation Presented) A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed α-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.

NOVEL PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS

HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Method of making and methods of using the compounds are also provided.

Synthesis and aldose reductase inhibitory activities of novel N-nitromethylsulfonanilide derivatives

A novel series of 14 N-nitromethylsulfonanilide derivatives were synthesized and evaluated for their ability to inhibit recombinant aldose reductase. Computational docking simulations provided a good explanation for the observed structure-activity relatio

1H-benzotriazol-1-yl methanesulfonate: A regioselective N-mesylating reagent

1H-Benzotriazol-1-yl methanesulfonate has been found to be an effective reagent in selective mesylation for differentiating amine groups from one another. In a molecule with both primary and secondary amine groups, mesylation only occurred at the primary amine group. When a compound contains both amine and hydroxy groups, the reagent selectively mesylated at the amine groups.

Aminolysis of sulfinamoyl-esters, -sulfonamides and -sulfones. Thiooxamate and thiourea formation via a sulfine intermediate. Thiophilic or carbophilic reaction?

The aminolysis process of sulfinamoyl derivatives was investigated with sulfinamoyl esters. An intermediate sulfine was unambiguously evidenced by formation of a Diels-Alder type adduct. The aminolysis leads to final thiooxamate products. A carbophilic addition was suggested for the reaction with secondary amines. With sulfinamoyl, -sulfones and -sulfonamides, a thiourea is formed resulting from a double aminolysis.

SUBSTITUENT EFFECT TREATMENT OF INTERACTIONS BETWEEN CONTIGUOUS FUNCTIONALITIES. IV. RESTRAINT TO PHENYL-NITROGEN CONJUGATIVE INTERACTION IN N-FUNCTIONALIZED N-METHYLANILINES

13C shifts at the para position in PhN(Me)X for 17 different substituents X serve as monitors for investigating, in correlative analysis, the nature and the extent of interactions occurring between the substituent X and the N-Me cavity.For the majority of substituent, X, partitioning of the nitrogen electron pair between the phenyl and the substituent is partially hampered because of the non-zero twist angle between the planes containing the phenyl ring and the Me-N-X fragment.As a consequence, relative to PhNHX, the interactions between the cavity and the substituents are increased in intensity, especially their mesomeric component, and, at the same time, para-13C shifts are displaced toward lower field.Evidence is also provided that possible H-bonding by the NH cavity of PhNHX with dimethyl sulphoxide does not appreciably influence the substituent electron demand determined previously.