132294-19-0Relevant academic research and scientific papers
A practical asymmetric synthesis of the antiviral agent lobucavir, BMS-180194
Singh, Janak,Bisacchi, Gregory S.,Ahmad, Saleem,Godfrey Jr., Jollie D.,Kissick, Thomas P.,Mitt, Toomas,Kocy, Octavian,Vu, Truc,Papaioannou, Chris G.,Wong, Michael K.,Heikes, James E.,Zahler, Robert,Mueller, Richard H.
, p. 393 - 399 (2013/09/08)
A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]- 6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, dibenzoate e
Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues
Bisacchi,Braitman,Cianci,Clark,Field,Hagen,Hockstein,Malley,Mitt,Slusarchyk,Sundeen,Terry,Tuomari,Weaver,Young,Zahler
, p. 1415 - 1421 (2007/10/02)
The syntheses of the enantiomeric cyclobutyl guanine nucleoside analogues [1R-1α,2β,3α]- and [1S-1α,2β,3α]-2-amino-9-[2,3-bis(hydroxymethyl) cyclobutyl]-6H-purin-6-one (7 and 8, respectively) and the enantiomeric cyclobutyl adenine analogues [1R-1α,2β,3α]
Synthesis of SQ-33,054, a novel cyclobutane nucleoside with potent antiviral activity
Slusarchyk,Young,Bisacchi,Hockstein,Zahler
, p. 6453 - 6456 (2007/10/02)
The racemic, guanine-containing cyclobutane nucleoside SQ-33,054 (3) was synthesized in 8 steps from the cyclobutane diester 4.
