13230-80-3

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-N-(1-phenylethyl)acetamide is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block in the development of new drugs and medications.
Used in Drug Synthesis:
2-chloro-N-(1-phenylethyl)acetamide is used as a key component in the synthesis of specific drugs, contributing to their therapeutic properties and effectiveness. Its presence in the molecular structure of these drugs allows for targeted interactions with biological targets, leading to desired pharmacological effects.

InChI:InChI=1/C10H12ClNO/c1-8(12-10(13)7-11)9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,12,13)

Upstream product

• 593-71-5 Chloroiodomethane 
• 14649-03-7 1-phenylethylisocyanate 
• 98-85-1 1-Phenylethanol 
• 107-14-2 chloroacetonitrile 
• 79-04-9 chloroacetyl chloride 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 1000291-21-3 C₂₇H₂₈N₄O₂S 
• 1000291-25-7 C₂₆H₃₂N₄O₂S 
• 1000291-27-9 C₂₇H₃₄N₄O₂S 
• 1000291-26-8 C₂₆H₃₁ClN₄O₂S 
• 1000291-19-9 C₂₆H₂₅ClN₄O₂S 
• 1305180-48-6 C₂₀H₂₃N₉O₃S₂ 
• 1180656-65-8 1,4-dihydro-9-hydroxy-8,9-dimethyl-2-(1-phenylethyl)-1,4-ethanoisoquinolin-3(2H)-one 

Relevant academic research and scientific papers

Magnetite-supported sulfonic acid: A retrievable nanocatalyst for the Ritter reaction and multicomponent reactions

Magnetite-sulfonic acid (Nanocat-Fe-OSO3H), prepared by the wet-impregnation method, serves as a magnetically retrievable sustainable catalyst for the Ritter and multicomponent reactions. The as synthesized catalyst can be used in several reaction cycles without any loss of activity.

Modified BINOL podands: Synthesis of dinaphthosulfide podands and their application in spectrophotometric determination of toxic metals

New dinaphthosulfide podands [3(a, b, and c)] were synthesized. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, and Mass spectra. A simple, efficient, and sensitive procedure is described for the spectrophotometric determination of a trace amount of Ag+, Hg2+, Cr3+, Pb2+, and Ni2+ cations in the presence of Mn2+, Co2+, Cd2+ cations using the podand (3a). Formation constants of 1:1 complexes were determined from the absorbance-mole ratio data and found to vary in the order Pb2+ Ni2+ Hg2+ Cr3+ Ag+.

External trapping of halomethyllithium enabled by flow microreactors

This work demonstrates that the accurate control of the reaction parameters realized within microreactor systems allowed for a taming of the reactivity of thermally unstable intermediates such as haloalkyllithiums. The first example of effective external trapping of a reactive carbenoid such as the chloromethyllithium is described. By using microreactor systems, a continuous flow synthesis of chloro alcohols and chloro amines could be achieved with high yields. By controlling the residence time the highly reactive chloromethyllithium could be generated and reacted with electrophiles at temperatures much higher than in batch-mode and without internal quenching. The developed continuous-flow process matches the requirements for sustainability.

Homologation of isocyanates with lithium carbenoids: A straightforward access to α-halomethyl- and α,α-dihalomethylamides

Treatment of widely available isocyanates with monohalolithium and dihalolithium carbenoids provides a valuable protocol for the one-pot preparation of α-halo- and α,α-dihaloacetamide derivatives. While monohalolithium carbenoids can be prepared by a smoo

Preparation of different amides via Ritter reaction from alcohols and nitriles in the presence of silica-bonded N-propyl sulphamic acid (SBNPSA) under solvent-free conditions

A number of methods have been proposed for the modification of the Ritter reaction. However, many of these methods involve the use of strongly acidic conditions, stoichiometric amounts of reagents, harsh reaction conditions and extended reaction times. Th

Sulfated tungstate: An efficient catalyst for the Ritter reaction

The use of sulfated tungstate as an efficient and reusable catalyst for the preparation of amides from alcohols and nitriles via the Ritter reaction pathway is discussed. The reaction proceeds under solvent free conditions. The Royal Society of Chemistry.

Selective synthesis of isoquinolin-3-one derivatives combining Pd-catalysed aromatic alkylation/vinylation with addition reactions: The beneficial effect of water

The three-component, palladium/norbornene-catalysed reaction of 1, haloamides 2 and properly substituted olefins 3 performed in DMF/water at: 80 °C selectively gave 5 and 6 through three- and. four-bond-forming reactions, respec tively. The presence of water was crucial to obtain products in fair to good yields,

Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents

The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/alkyl-5-(1-phenoxyethyl)-3-[N-(substituted) acetamido]thio-4H-1,2,4-t

Synthetic study of 4-substituted piperidine ring in elarofiban, RWJ-50042, tirofiban and paroxetine

A new strategy for synthesizing a 4-substituted piperidine ring uses the formal [3+3] cycloaddition reaction as the key protocol. This method provides a convenient formal synthesis of elarofiban, RWJ-50042, tirofiban and paroxetine.

Silica gel supported ferric perchlorate: A new and efficient reagent for one pot synthesis of amides from benzylic alcohols

Benzylic alcohols react efficiently with nitriles in the presence of silica gel supported ferric perchlorate to produce amides in high yields.