1323158-99-1

Basic information

• Product Name: N'-(morpholin-4-ylmethylidene)benzohydrazide
• Synonyms: N'-(morpholin-4-ylmethylidene)benzohydrazide
• CAS NO: 1323158-99-1
• Molecular Weight: 233.27
• Mol File: 1323158-99-1.mol

Chemical Properties

• CAS DataBase Reference: N'-(morpholin-4-ylmethylidene)benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(morpholin-4-ylmethylidene)benzohydrazide(1323158-99-1)
• EPA Substance Registry System: N'-(morpholin-4-ylmethylidene)benzohydrazide(1323158-99-1)

Safety Data

• Hazardous Substances Data: 1323158-99-1(Hazardous Substances Data)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 110-91-8 morpholine 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 

Downstream Products

• 23767-49-9 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6- tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant

No transition metals are necessary to convert benzoxazoles and 1,3,4-oxadiazoles into the corresponding pharmacologically interesting 2-aminated heterocycles by formal direct C(2)-amination using tetramethylpiperidine-N-oxoammonium tetrafluoroborate (TEMPO+BF 4-) as an oxidant (see scheme; TEMP=2,2,6,6- tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

A metal-free route to 2-aminooxazoles by taking advantage of the unique ring opening of benzoxazoles and oxadiazoles with secondary amines

Toss an amine into the ring: A new metal-free protocol for the amination of oxazoles has been developed by using iodobenzene diacetate to couple various oxazoles with amines (see scheme). The reaction proceeds through a ring-opening and subsequent ring-closing pathway. The optimal conditions are very mild and the substrate scope is broad, producing a range of 2-aminooxazoles, an important pharmacophore with high bioactivity. Copyright