23767-49-9

Basic information

• Product Name: 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole
• CAS NO: 23767-49-9
• Molecular Weight: 231.254
• Mol File: 23767-49-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole(23767-49-9)
• EPA Substance Registry System: 2-(morpholin-4-yl)-5-phenyl-1,3,4-oxadiazole(23767-49-9)

Safety Data

• Hazardous Substances Data: 23767-49-9(Hazardous Substances Data)

Upstream product

• 23328-69-0 4-chloromorpholine 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 110-91-8 morpholine 
• 1323158-99-1 C₁₂H₁₅N₃O₂ 
• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 10465-97-1 N-benzoyl-N'-ethoxycarbonyl hydrazine 
• 1483-31-4 2-chloro-5-phenyl-1,3,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 1323158-99-1 N'-(morpholin-4-ylmethylidene)benzohydrazide 

Relevant articles and documents

CuII/H-USY as a regenerable bifunctional catalyst for the additive-free C-H amination of azoles

A copper-exchanged H-USY zeolite catalyst was developed for the direct C-H amination of azoles with secondary amines in HFIP. The reaction was performed under air without any external additive. The Cu/H-USY catalyst could be regenerated for further re-use without significant decrease in activity.

A metal-free route to 2-aminooxazoles by taking advantage of the unique ring opening of benzoxazoles and oxadiazoles with secondary amines

Toss an amine into the ring: A new metal-free protocol for the amination of oxazoles has been developed by using iodobenzene diacetate to couple various oxazoles with amines (see scheme). The reaction proceeds through a ring-opening and subsequent ring-closing pathway. The optimal conditions are very mild and the substrate scope is broad, producing a range of 2-aminooxazoles, an important pharmacophore with high bioactivity. Copyright

A new entry of amination reagents for heteroaromatic C-H bonds: Copper-catalyzed direct amination of azoles with chloroamines at room temperature

Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.