132329-46-5

Upstream product

• 1476-11-5 Z-1,4-dichlorobutene 
• 16836-95-6 silver(I) 4-methylbenzenesulfonate 
• 6117-80-2 1,4-butenediol 
• 98-59-9 p-toluenesulfonyl chloride 
• 821-11-4 1,4-butenediol 

Downstream Products

• 6728-08-1 trans-1,4-bis(phenylsulfanyl)-2-buene 
• 1267636-38-3 (Z)-dimethyl-2,2,7,7-tetraphenyloct-4-enedioate 
• 7686-78-4 diethyl 2-vinylcyclopropane-1,1-dicarboxylate 
• 303734-03-4 (Z)-1-fluoro-4-tosyloxybut-2-ene 

Relevant academic research and scientific papers

One-step, enantiospecific transformation of cyclic, five-membered-1, 2-diols into their respective 1,2-bis(phenylsulfanyl) derivatives

The enantiomeric cyclic, five-membered vic-diols reacted with (PhS) 2/Bu3P in benzene at 80 °C giving the corresponding bis(phenylsulfanyl) derivatives (42-74%) with complete inversion of configuration at both stereogenic centers. Si

Formal [5+1] annulation reactions of dielectrophilic peroxides: Facile access to functionalized dihydropyrans

A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.

Disulfonic acid ester compound for preparing olefin polymerization catalyst

The invention relates to a disulfonic acid ester compound for preparing an olefin polymerization catalyst. The disulfonic acid ester compound is shown in the general formula (I), wherein A and B are carbon or hetero atoms selected from nitrogen, oxygen, s

Preparation of 1-tosyloxy-4-substituted-2-butenes using Ag(I) salts

Abstract The trans-fluoro-2-butenyl group has been previously utilized as an N-substituent on several nortropanes for imaging the dopamine transporter with positron emission tomography. We report here a simplified and shorter synthesis of trans-1-tosyloxy

Allyl sulphides in olefin metathesis: Catalyst considerations and traceless promotion of ring-closing metathesis

Allyl sulphides are reactive substrates in ruthenium-catalysed olefin metathesis reactions, provided each substrate is matched with a suitable catalyst. A profile of catalyst activity is described, along with the first demonstration of allyl sulphides as traceless promoters in relayed ring-closing metathesis reactions. This journal is

METHOD FOR PRODUCING 1-AMINO-1-ALKOXYCARBONYL-2-VINYLCYCLOPROPANE

It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.

Enantioselective haloetherification by asymmetric opening of meso -halonium ions

A new approach to enantioselective haloetherification reactions via desymmetrization of in situ-generated meso-halonium ions is described. The combination of N-haloamides as a halogen source and sodium salts of chiral phosphoric acids as catalysts can be used for the cyclization of symmetrical ene-diol substrates, yielding the haloetherification products under practical conditions in enantioenriched form.(Figure Presented)

Fluoralkenyl nortropanes

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

Stereocontrolled Preparation of (Z)-1,4-but-2-endiol Esters in Phase-Transfer Conditions

Isomerically pure esters of (Z)-1,4-but-2-endiol are prepared, in satisfactory yields, under phase-transfer conditions.