132350-98-2Relevant academic research and scientific papers
Catalytic Asymmetric Synthesis of Optically Active Alkynyl Alcohols
Soai, Kenso,Niwa, Seiji
, p. 481 - 484 (1989)
Enantioselective additions of dialkylzinc reagents to alkynyl aldehydes using (S)-(+)-diphenyl(1-methylpyrrolidin-2-yl)methanol as a chiral catalyst afford optically active sec-alkynyl alcohols in high enantiomeric excess.
Facile preparation of optically pure 7,7′-disubstituted BINOLS and their application in asymmetric catalysis
Liu, Quan-Zhong,Xie, Nan-Sheng,Luo, Zhi-Bin,Cui, Xin,Cun, Lin-Feng,Gong, Liu-Zhu,Mi, Ai-Qiao,Jiang, Yao-Zhong
, p. 7921 - 7924 (2007/10/03)
A family of optically pure 7,7′-disubsituted-2,2′ -dihydroxy-1,1′-dinaphthyls have been conveniently prepared from easily accessible 7-alloxyl-2-naphthol by reaction sequences beginning with the asymmetric oxidative coupling and followed by key synthetic steps including deprotection, alkylation, and Suzuki coupling. Application of these binaphthols in catalytic phenylacetylene addition to aldehydes resulted in excellent enantioselectivities.
Catalytic Asymmetric Synthesis of Optically Active Alkynyl Alcohols by Enantioselective Alkynylation of Aldehydes and by Enantioselective Alkylation of Alkynyl Aldehydes
Niwa, Seiji,Soai, Kenso
, p. 937 - 943 (2007/10/02)
Catalytic asymmetric synthesis of optically active secondary alkynyl alcohols (1) by enantioselective addition of organozinc reagents to aldehydes in the presence of a small amount of catalyst was examined.Enantioslective alkynylation of benzaldehyde by a
