Catalytic Asymmetric Synthesis of Optically Active Alkynyl Alcohols

Article abstract of DOI:10.1246/cl.1989.481

Enantioselective additions of dialkylzinc reagents to alkynyl aldehydes using (S)-(+)-diphenyl(1-methylpyrrolidin-2-yl)methanol as a chiral catalyst afford optically active sec-alkynyl alcohols in high enantiomeric excess.