13237-43-9Relevant academic research and scientific papers
Solid dispersions containing an apoptosis-inducing agent
-
Page/Page column 198, (2019/03/15)
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors
St-Denis, Yves,Levesque, Sophie,Bachand, Benoit,Edmunds, Jeremy J.,Leblond, Lorraine,Preville, Patrice,Tarazi, Micheline,Winocour, Peter D.,Siddiqui, M. Arshad
, p. 1181 - 1184 (2007/10/03)
The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compou
