473923-79-4

Basic information

• Product Name: TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE
• Synonyms: TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE ;trans-(4-Cyano-cyclohexylmethyl)-carbamic acid tert-butyl ester;tert-butyl (((1r,4r)-4-cyanocyclohexyl)methyl)carbamate;(4-Cyanocyclohexylmethyl)-carbamic acid tert-butyl ester and enantiomer
• CAS NO: 473923-79-4
• Molecular Formula: C₁₃H₂₂N₂O₂
• Molecular Weight: 238.32598
• Mol File: 473923-79-4.mol

Chemical Properties

• Boiling Point: 384°Cat760mmHg
• Flash Point: 186°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE(473923-79-4)
• EPA Substance Registry System: TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE(473923-79-4)

Safety Data

• Hazardous Substances Data: 473923-79-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE serves as a crucial building block in the synthesis of various pharmaceuticals. Its BOC protective group prevents unwanted side reactions during the synthesis process, ensuring the selective formation of desired products.
Used in Organic Chemistry:
In the field of organic chemistry, TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE is utilized as an intermediate for the preparation of a wide range of organic compounds. The BOC group can be removed under mild conditions to reveal the free amino group, allowing for further functionalization and modification of the molecule.
Used in the Production of Biologically Active Compounds:
TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBONITRILE is an important intermediate for the synthesis of biologically active compounds and materials. Its unique structure and functional groups enable the development of new molecules with potential applications in medicine, agriculture, and other industries.

InChI:InChI=1/C13H22N2O2/c1-13(2,3)17-12(16)15-9-11-6-4-10(8-14)5-7-11/h10-11H,4-7,9H2,1-3H3,(H,15,16)/t10-,11-

Upstream product

• 27687-14-5 trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid 
• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 72009-69-9 (4-cyano-cyclohexylmethyl)-carbamic acid benzyl ester 
• 38688-25-4 (4-Carbamoyl-cyclohexylmethyl)-carbamic acid benzyl ester 
• 27687-12-3 (1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid 
• 407-25-0 trifluoroacetic anhydride 
• 749866-15-7 trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide 
• 13237-43-9 trans-4-(aminomethyl)cyclohexanecarbonitrile 

Downstream Products

• 166168-16-7 trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester 
• 917022-13-0 C₃₁H₅₃ClN₆O₄ 
• 1191450-19-7 (x)BrH*C₂₇H₅₁N₈O₃P 
• 13237-43-9 trans-4-(aminomethyl)cyclohexanecarbonitrile 

Relevant articles and documents

INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE

The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

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A convenient new procedure for converting primary amides into nitriles

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Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors

The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compou