38688-25-4Relevant articles and documents
Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors
St-Denis, Yves,Levesque, Sophie,Bachand, Benoit,Edmunds, Jeremy J.,Leblond, Lorraine,Preville, Patrice,Tarazi, Micheline,Winocour, Peter D.,Siddiqui, M. Arshad
, p. 1181 - 1184 (2007/10/03)
The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compou