132376-67-1

Basic information

• Product Name: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID
• Synonyms: RARECHEM BK HD 0006;(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID;(2E)-3-(1-benzofuran-2-yl)acrylic (2E)-3-(1-Benzofuran-2-Yl)Acrylic Acid(WX610378)
• CAS NO: 132376-67-1
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.18
• Mol File: 132376-67-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(132376-67-1)
• EPA Substance Registry System: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(132376-67-1)

Safety Data

• Hazardous Substances Data: 132376-67-1(Hazardous Substances Data)

Usage

General Description

(2E)-3-(1-benzofuran-2-yl)acrylic acid is a chemical compound with the molecular formula C11H8O3. It is a derivative of acrylic acid with a benzofuran group attached to the double bond, resulting in a conjugated system of double bonds. (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block for more complex molecules. The presence of the benzofuran group makes it biologically active, and it has shown promising pharmacological properties in some studies. Its conjugated structure also gives it potential use in materials science, such as in the development of organic electronic devices or as a dye or pigment. Overall, (2E)-3-(1-benzofuran-2-yl)acrylic acid is a versatile compound with potential applications in various fields of chemistry and biology.

Upstream product

• 141-82-2 malonic acid 
• 4265-16-1 2-formylbenzo[b]furan 
• 76268-18-3 C₁₆H₁₄N₂O₄S 
• 42974-19-6 benzo[b]furan-2-carbohydrazide 
• 3199-61-9 ethyl coumarilate 
• 271-89-6 1-benzofurane 
• 125482-23-7 (E)-ethyl 3-(2-benzofuryl)acrylate 
• 748752-63-8 (rac)-2-amino-3-benzofuran-2-yl-propionic acid 
• 91909-84-1 ethyl 3-(benzo[b]furan-2-yl)propionate 

Downstream Products

• 1075220-98-2 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-96-0 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-benzyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-97-1 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(3-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-99-3 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 144829-19-6 dihydro-5-([2'-hydroxyphenyl]methyl)-2(3H)-furanone 
• 21683-86-3 3-(Benzofuran-2-yl)propionic acid 

Relevant articles and documents

Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2′-furyl)propanoic acid derivatives to give butanolides: Mechanism and scope

The mechanisms by which dihydro-5-(3′-trifluoroacetoxypropyl)-2(3H)-furanone is formed when 3-(tetrahydro-2′- furyl)propanoic-trifluoroacetic mixed anhydride is treated with an acidic catalyst is defined, and routes to some potentially useful butanolide synthons are described.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

The interaction of heteroaryl-acrylates and alanines with phenylalanine ammonia-lyase from parsley

Acrylic acids and alanines substituted with heteroaryl groups at the β-position were synthesized and spectroscopically characterized (UV, HRMS, 1H NMR, and 13C NMR spectroscopy). The heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl and contained the alanyl side chains either at the 2- or 3-positions. While the former are good substrates for phenylalanine ammonia lyase (PAL), the latter compounds are inhibitors. Exceptions are thiophen-3-yl-alanine, a moderate substrate and furan-3-yl-alanine, which is inert. Possible reasons for these exceptions are discussed. Starting from racemic het eroaryl-2-alanines their D-enantiomers were prepared by using a stereodestructive procedure. From the heteroaryl-2- acrylates, the L-enantiomers of the heteroaryl-2-alanines were prepared at high ammonia concentration. These results can be best explained by a Friedel - Crafts-type electrophilic attack at the aromatic part of the substrates as the initial step of the PAL reaction.