132391-36-7

Upstream product

• 148214-94-2 ethyl 1,4-dihydro-2-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-5-pyridinecarboxylate 
• 626-34-6 ethyl aminocrotonate 
• 1772-77-6 methyl 4-(3-nitrophenyl)-2-oxo-3-butenoate 
• 148214-95-3 ethyl 2-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-5-pyridinecarboxylate 

Downstream Products

• 148214-96-4 ethyl 6-amino-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylate 
• 148214-97-5 ethyl 2-bromoacetylamino-6-methyl-4-(3-nitrophenyl)-5-pyridinecarboxylate 

Relevant academic research and scientific papers

Studies on cerebral protective agents. V. Novel 4-(3-nitrophenyl)pyridine and 4-(3-nitrophenyl)pyrimidine derivatives with anti-anoxic activity

Novel 4-(3-nitrophenyl)pyridine and 4-(3-nitrophenyl)pyrimidine derivatives, possessing three-atom linkages between basic nitrogen and at the C-5 (or C-3) position of the pyrimidine (or pyridine) ring, were synthesized and tested for anti-anoxic (AA) activity in mice. Among them, 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-(pyrrolidinomethylcarbonylamino) pyrimidine (10f) had the most potent AA activity (3.2 mg/kg, i.p.). Three-dimensional molecular electrostatic potentials (3D-MEP) around the nitrogeneous basic moiety of 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenyl pyrimidine (FK 360) and 10f were compared. The negative zone of 10f is broader and deeper and positioned somewhat differently to that of FK 360, although there is a co-occupied spacial area in part.