13245-63-1

Basic information

• Product Name: Tetrachlorofluorescein
• Synonyms: 3,4,5,6-Tetrachlorofluorescein; 4,5,6,7-Tetrachloro-3',6'-dihydroxyspiro(isobenzofuran- 1(3H),9'-(9H)xanthene)-3-one; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4,5,6,7- tetrachloro-3',6'-dihydroxy-; Tetrachloro fluorescein; 4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one; 2,3,4,5-tetrachloro-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
• CAS NO: 13245-63-1
• Molecular Formula: C₂₀H₈Cl₄O₅
• Molecular Weight: 0
• EINECS: 228-413-3
• Mol File: 13245-63-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 725.6°C at 760 mmHg
• Flash Point: 392.6°C
• Appearance: /
• Density: 1.8g/cm³
• Vapor Pressure: 4.23E-22mmHg at 25°C
• Refractive Index: 1.768
• CAS DataBase Reference: Tetrachlorofluorescein(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrachlorofluorescein(13245-63-1)
• EPA Substance Registry System: Tetrachlorofluorescein(13245-63-1)

Safety Data

• Hazardous Substances Data: 13245-63-1(Hazardous Substances Data)

Usage

General Description

Tetrachlorofluorescein, also known as eosin Y, is a synthetic organic compound that belongs to the class of fluorone dyes. It is a bright red solid that is commonly used as a fluorescent tracer for biological research and as a coloring agent in various industrial applications. Tetrachlorofluorescein is also used in medical diagnostics as a staining agent for tissues and cells. It is known for its high photostability, allowing it to be used in long-term imaging studies. Additionally, it has been investigated for its potential use in photodynamic therapy for cancer treatment. Overall, tetrachlorofluorescein is a versatile chemical with a range of applications in research, industry, and medicine.

InChI:InChI=1/C20H8Cl4O5/c21-16-14(15(20(27)28)17(22)19(24)18(16)23)13-9-3-1-7(25)5-11(9)29-12-6-8(26)2-4-10(12)13/h1-6,25H,(H,27,28)

Upstream product

• 117-08-8 tetrachlorophthalic anhydride 
• 108-46-3 recorcinol 
• 632-58-6 tetrachlorophthalic acid 
• 21811-70-1 2,3,4,5-tetrachloro-6-(2,4-dihydroxy-benzoyl)-benzoic acid 

Downstream Products

• 2134-15-8 2,4,5,7-tetrabromo-1',2',3',4'-tetrachlorofluorescein 
• 152-74-9 Rose-Bengale 

Relevant articles and documents

Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein engineering to sensitize a target enzyme to inhibition by a small molecule that does not inhibit homologous wild-type enzymes. Previously, it has been shown that protein tyrosine phosphatases (PTPs) can be sensitized to inhibition by a biarsenical probe, FlAsH-EDT2, which inhibits PTP activity by specifically binding to cysteine residues that have been introduced into catalytically important regions. In the present study, we developed an array of biarsenical probes, some newly synthesized and some previously reported, to investigate for the first time the structure-activity relationships for PTP inhibition by biarsenicals. Our data show that biarsenical probes which contain substitutions at the 2′ and 7′ positions are more effective than FlAsH-EDT2 at inhibiting sensitized PTPs. The increased potency of 2′,7′-substituted probes was observed when PTPs were assayed with both para-nitrophenylphosphate and phosphopeptide PTP substrates and at multiple probe concentrations. The data further indicate that the enhanced inhibitory properties are the result of increased binding affinity between the 2′,7′-substituted biarsenical probes and sensitized PTPs. In addition we provide previously unknown physicochemical and stability data for various biarsenical probes.

POLYHALOGENATED FLUORESCEINS IN PHOTOCATALYTIC SYSTEMS WITH HYDROGEN EVOLUTION

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