132452-42-7Relevant academic research and scientific papers
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00101; 00104-00105, (2021/08/13)
The present invention provides compounds, compositions thereof, and methods of using the same.
Solid dispersions containing an apoptosis-inducing agent
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Page/Page column 257, (2019/03/15)
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
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Page/Page column 101, (2019/11/28)
Provided herein are dihydropyrimidine derivatives which are useful in the treatment of HBV infection or HBV-induced diseases, as well as pharmaceutical or medical applications thereof.
Aminoheteroaryl benzamides as kinase inhibitors
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Page/Page column 425; 416; 417, (2016/02/15)
The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
BORON COMPOUND WITH AMINO ACID SKELETON CONTAINING CYCLO RING
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Paragraph 0094; 0095, (2013/06/27)
The purpose of the present invention is to provide a novel boron-containing compound utilizable in BNCT and so on and a process for preparing same. According to the process, a boron compounds having an amino acid skeleton containing cyclo-type rings or a
BICYCLIC DERIVATIVES AS CETP INHIBITORS
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Page/Page column 86; 87, (2008/06/13)
The present invention relates to novel compounds of formula (I): or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay
Synthesis and Pharmacological Evaluation of Hexahydrofluorenamines as Noncompetitive Antagonists at the N-Methyl-D-aspartate Receptor
Hays, Sheryl J.,Novak, Perry M.,Ortwine, Daniel F.,Bigge, Christopher F.,Colbry, Norman L.,et al.
, p. 654 - 670 (2007/10/02)
The noncompetitive (PCP) site of the N-methyl-D-aspartate (NMDA) receptor complex has been implicated in a number of pathologies, including the etiology of ischemic stroke.Recent testing has shown that cis-1,2,3,4,9,9a-hexahydro-N-methyl-4aH-fluoren-4a-am
