132454-68-3

Upstream product

• 41107-64-6 Acetic acid (3aR,5R,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 14260-66-3 ((3αR,5S,6αR)-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 97551-58-1 5-O-acetyl-3-deoxy-1,2-O-isopropylidene-α-D-erythropentose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 84218-90-6 1,2-O-isopropylidene-3-O<(methylthio)thiocarbonyl>-5-O-trityl-α-D-xylofuranose 
• 84218-91-7 3-deoxy-1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose 
• 116306-89-9 (3αR,5S,6αR)-5-(benzyloxymethyl)-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxole 
• 3396-71-2 3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 532-20-7 α-D-xylofuranose 
• 114861-25-5 (2S,3R,5S)-5-Benzyloxymethyl-tetrahydro-furan-2,3-diol 
• 114861-25-5 (3R,5S)-5-(benzyloxymethyl)tetrahydrofuran-2,3-diol 
• 20590-53-8 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 

Downstream Products

• 133765-68-1 (4R,6S)-6-benzyloxymethyl-4-t-butyldimethylsilyloxytetrahydro-2-pyrone 
• 1272971-46-6 (3R,5S)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3-(benzyloxy)-5-(benzyloxymethyl)tetrahydrofuran-2-carbonitrile 
• 1238580-28-3 (3R,5S)-3-(benzyloxy)-5-(benzyloxymethyl)dihydrofuran-2(3H)-one 
• 132454-81-0 (2S,4S)-4-Benzyloxymethyl-oxetane-2-carboxylic acid methyl ester 
• 133765-69-2 (3R,5S)-5-Benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-dihydro-furan-2-one 
• 132454-67-2 Trifluoro-methanesulfonic acid (3R,5S)-5-benzyloxymethyl-2-oxo-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (I): wherein the 1 ? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections

Enantioselective Synthesis of the Lactone Moiety of the Mevinic Acids using D-Xylose as a Chiral Precursor

Homologation of the lactone 14 easily obtained from D-xylose afforded the pyranone 15, a key chiral synthon for the lactone portion of mevinic acids.

Ring contraction of 3-deoxy-2-O-trifluoromethanesulphonates of α-hydroxy-γ-lactones to oxetanes

The ring contraction of α-triflates of 3-deoxy-1,4-lactones bearing hydrogen or alkyl substituents in the 3-position to methyl oxetane-2-carboxylates on treatment with potassium carbonate in methanol is described.