116306-89-9

Upstream product

• 3396-71-2 3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 41107-64-6 Acetic acid (3aR,5R,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 14260-66-3 ((3αR,5S,6αR)-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 97551-58-1 5-O-acetyl-3-deoxy-1,2-O-isopropylidene-α-D-erythropentose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 20590-53-8 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 84218-90-6 1,2-O-isopropylidene-3-O<(methylthio)thiocarbonyl>-5-O-trityl-α-D-xylofuranose 
• 84218-91-7 3-deoxy-1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose 
• 532-20-7 α-D-xylofuranose 
• 4613-62-1 3-deoxy-1,2;5,6-di-O-isopropylidene-α-D-glucofuranoside 
• 4005-46-3 3-deoxy-1,2-O-isopropylidene-D-glucose 

Downstream Products

• 178860-74-7 (2S,4R)-2,4-((S)-benzylidenedioxy)-1-benzyloxy-16-methylheptadec-5(E/Z)-ene 
• 132813-62-8 methyl 5-O-benzyl-3-deoxy-β-D-ribofuranoside 
• 1238580-28-3 (3R,5S)-3-(benzyloxy)-5-(benzyloxymethyl)dihydrofuran-2(3H)-one 
• 1272971-46-6 (3R,5S)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3-(benzyloxy)-5-(benzyloxymethyl)tetrahydrofuran-2-carbonitrile 
• 132454-67-2 Trifluoro-methanesulfonic acid (3R,5S)-5-benzyloxymethyl-2-oxo-tetrahydro-furan-3-yl ester 
• 132454-81-0 (2S,4S)-4-Benzyloxymethyl-oxetane-2-carboxylic acid methyl ester 
• 92757-18-1 (4R,6S)-6-(benzyloxy)methyl-4-hydroxy-tetrahydro-2-pyrone 
• 132454-68-3 (3R,5S)-5-(benzyloxymethyl)-3-hydroxy-dihydrofuran-2(3H)-one 
• 116306-95-7 (2R,3R,5S)-6-O-benzyl-2,3-O-isopropylidene-5-O-<(2-methoxyethoxy)methyl>-2,3,5,6-tetrahydroxyhexanal 
• 116306-94-6 (2S,3R,5S)-6-O-benzyl-2,3-O-isopropylidene-5-O-<(2-methoxyethoxy)methyl>-2,3,5,6-tetrahydroxyhexanal 
• 116307-03-0 (2S,3R,5S)-5,6-di-O-benzyl-2,3-O-isopropylidene-2,3,5,6-tetrahydroxyhexanal 
• 116328-99-5 methyl (2S,3R,5R)-6-O-benzyl-2,3-O-isopropylidene-2,3,5-trihydroxyhexanoate 
• 116306-97-9 (4S,5R)-5-((S)-3-Benzyloxy-2-hydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 

Relevant academic research and scientific papers

METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (I): wherein the 1 ? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections

Synthesis of thietane nucleoside with an anomeric hydroxymethyl group

Thietane nucleoside 5 with an anomeric hydroxymethyl group was synthesized via the Pummerer reaction. The stereochemistry of the sulfoxide and the nature of the protecting group had no significant effect on the yield of the reaction. When a hypervalent iodine reagent was used, sulfide 16 with O-benzoyl protecting groups gave the ring-expanded nucleoside 21. Unfortunately, synthesized compound 6 did not exhibit anti-HSV activity. Copyright

A general strategy for the formal synthesis of (-)-trans-kumausyne and total synthesis of (5R)-Hagen's gland lactones from diacetone-D-glucose

A general strategy for the formal synthesis of (-)-trans-kumausyne 1 via the bicyclic lactone (3aR,5R,6aR)-4 and total synthesis of (5R)-Hagen's gland lactones 2 and 3 via bicyclic lactone (3aR,5S,6aR)-5 starting from diacetone-D-glucose 6 is described. Syntheses of 4 and 5 were achieved by Wittig olefination-lactonization-Michael addition of the corresponding lactols 16 and 17, respectively. Copyright (C) 2000 Elsevier Science Ltd.

Revised structure and synthesis of flavolipin

The proposed structure of natural flavolipin was revised as N-[N-[(3R)- 15-methyl-3-(13-methyltetradecanoyloxy)hexadecanoyl]glycyl]-L-serine as a result of a synthetic study and biological activity tests, and its isomers synthesized in a stereocontrolled manner.

Synthesis of some pyrrolo[2,3-

The pynolo[2,3-d]pyrimidine isodideoxynucleosides 7,8, and 9, related to the (S.S)-enantiomers of iso-2',3'-dideoxy-adenosine, -inosine and -guanosine respectively, have been prepared from D-xylose. Copyright

Stereocontrolled synthesis of all stereoisomers of the proposed flavolipin

All four stereoisomers of flavolipin were synthesized from D-glucose in a stereocontrolled manner. None of them was identical with the reported natural product.

Enantioselective Synthesis of the Lactone Moiety of the Mevinic Acids using D-Xylose as a Chiral Precursor

Homologation of the lactone 14 easily obtained from D-xylose afforded the pyranone 15, a key chiral synthon for the lactone portion of mevinic acids.

Ring contraction of 3-deoxy-2-O-trifluoromethanesulphonates of α-hydroxy-γ-lactones to oxetanes

The ring contraction of α-triflates of 3-deoxy-1,4-lactones bearing hydrogen or alkyl substituents in the 3-position to methyl oxetane-2-carboxylates on treatment with potassium carbonate in methanol is described.