132464-84-7

Basic information

• Product Name: 5-IODO-2,3-DIHYDROBENZO[B]FURAN
• Synonyms: 2,3-DIHYDRO-5-IODOBENZO[B]FURAN;5-IODO-2,3-DIHYDROBENZO[B]FURAN;5-IODO-2,3-DIHYDROBENZOFURAN;BUTTPARK 36\18-19;2,3-Dihydro-5-iodo-1-benzofuran;5-iodo-2,3-dihydro-1-benzofuran
• CAS NO: 132464-84-7
• Molecular Formula: C₈H₇IO
• Molecular Weight: 246.05
• Mol File: 132464-84-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 62-65
• Boiling Point: 275.5 °C at 760 mmHg
• Flash Point: 120.4 °C
• Appearance: /
• Density: 1.869 g/cm³
• Vapor Pressure: 0.00852mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 5-IODO-2,3-DIHYDROBENZO[B]FURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-2,3-DIHYDROBENZO[B]FURAN(132464-84-7)
• EPA Substance Registry System: 5-IODO-2,3-DIHYDROBENZO[B]FURAN(132464-84-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 132464-84-7(Hazardous Substances Data)

Usage

General Description

5-IODO-2,3-DIHYDROBENZO[B]FURAN is a chemical compound with the molecular formula C8H7IO. It is a derivative of benzofuran and contains an iodine atom attached to the 5-position of the benzofuran ring. This chemical is a pale yellow crystalline solid with a molecular weight of 282.04 g/mol and a melting point of 129-133°C. It is used in organic synthesis and as a building block for the preparation of various pharmaceuticals and agrochemicals. 5-IODO-2,3-DIHYDROBENZO[B]FURAN has potential applications in the development of new drugs and in research related to the synthesis of complex organic molecules. Its unique structure and reactivity make it an important compound in the field of organic chemistry.

InChI:InChI=1/C8H7IO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5H,3-4H2

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 132464-81-4 4-(2-Chloro-phenyl)-2-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 132464-69-8 4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 132464-87-0 5-ethynyl-2,3-dihydrobenzofuran 
• 115063-19-9 1-(2,3-dihydrobenzofuran-5-yl)phenylmethanone 

Relevant articles and documents

MANUFACTURING METHOD OF AROMATIC IODINE COMPOUND USING DISULFIDE AS CATALYST

To manufacture an aromatic iodine compound under a mild condition at low cost and high yield.SOLUTION: There is provided a manufacturing method of an aromatic iodine compound by reacting an aromatic compound and an iodination agent in a presence of a cata

Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.

Mild arming and derivatization of natural products via an In(OTf) 3-catalyzed arene iodination

Figure presented Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)3 at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.