132464-87-0

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 
• 132464-84-7 5-iodo-2,3-dihydrobenzo[b]furan 

Downstream Products

• 132464-81-4 4-(2-Chloro-phenyl)-2-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 937594-68-8 5-[(3-bromophenyl)ethynyl]-2,3-dihydro-1-benzofuran 
• 84944-75-2 5-cyano-2,3-dihydrobenzofuran 
• 132464-69-8 4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.

Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2

The preparations of thienotriazolodiazepines bearing a substituted ethynyl group at the 2-position, and the corresponding cis-olefins and fully saturated analogues are described. The compounds were evaluated as potential antagonists of platelet-activating