132465-03-3Relevant academic research and scientific papers
Stereochemistry of Knoevenagel condensation products from cyanoacetates and aromatic aldehydes
Cho,Iwashita,Hamaguchi,Oyama
, p. 3341 - 3342 (1991)
The C-13 long-range selective proton decoupling method and X-ray crystallographic analysis were employed to determine the stereochemistry of the caffeic acid derivatives, extremely potent 12-lipoxygenase inhibitors, synthesized from cyanoacetates and arom
Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel
Rodrigues, Nuno,Bennis, Khalil,Vivier, Delphine,Pereira, Vanessa,Chatelain, Franck C.,Chapuy, Eric,Deokar, Hemantkumar,Busserolles, Jér?me,Lesage, Florian,Eschalier, Alain,Ducki, Sylvie
supporting information, p. 391 - 402 (2014/03/21)
The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs. It has been reported that TREK-1 -/- mice were more sensitive than wild-type mice to painful stimuli, suggesting that activation of TREK-1 could result in pain inhibition. Here we report the synthesis of a series of substituted caffeate esters (12a-u) based on the hit compound CDC 2 (cinnamyl 3,4-dihydroxyl-α-cyanocinnamate). These analogs were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid induced-writhing assay) leading to the identification a series of novel molecules able to activate TREK-1 and displaying potent analgesic activity in vivo.
DERIVATIVE OF CAFFEIC ACID AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
, (2008/06/13)
Novel derivatives of caffeic acid of the general formula (I): wherein X is hydrogen atom or hydroxy; R 1 is hydrogen atom, a straight or branched alkyl or alkenyl having 1 to 20 carbon atoms or a group of the formula wherein n is an integer of 1 to 10; Z
