99842-68-9

Basic information

• Product Name: Acetic acid, cyano-, 2-phenylethyl ester
• Synonyms: Acetic acid, cyano-, 2-phenylethyl ester
• CAS NO: 99842-68-9
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21054
• Mol File: 99842-68-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 102℃ at 13.332Pa
• Appearance: /
• CAS DataBase Reference: Acetic acid, cyano-, 2-phenylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, cyano-, 2-phenylethyl ester(99842-68-9)
• EPA Substance Registry System: Acetic acid, cyano-, 2-phenylethyl ester(99842-68-9)

Safety Data

• Hazardous Substances Data: 99842-68-9(Hazardous Substances Data)

Upstream product

• 60-12-8 2-phenylethanol 
• 105-56-6 ethyl 2-cyanoacetate 
• 372-09-8 cyanoacetic acid 
• 103-63-9 1-phenyl-2-bromoethane 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 15802-18-3 2-cyanoacrylic acid 
• 132465-03-3 phenethyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate 
• 132464-98-3 (E)-2-Cyano-3-(3-hydroxy-phenyl)-acrylic acid phenethyl ester 

Relevant articles and documents

PROCESS FOR PREPARING ELECTRON DEFICIENT OLEFIN PRECURSORS

This invention relates to a process for producing electron deficient olefin precursors, such as 2-cyanoacetates, using an acid catalyzed esterification reaction.

Palladium-Catalyzed Direct Arylation of C(sp3)-H Bonds of α-Cyano Aliphatic Amides

Pd(OAc)2-catalyzed arylation of C(sp3)-H bonds in α-cyano-α-methyl aliphatic amides is achieved in the presence of 8-aminoquinoline, as a removable directing group, using Mn(OAc)2 and Na2CO3. The current strategy enables the placement of an aryl/heteroaryl group at the β-position of α-cyano aliphatic acids for the first time. Wide functional group tolerance and easily accessible starting materials provide an efficient protocol for the synthesis of arylated α-cyano amides. Furthermore, the synthetic utility of the products has been demonstrated by their efficient conversions to medicinally important α,α-dialkylated acid and β-amino acid derivatives.

METHOD FOR THE PREPARATION OF PHOSPHINE BUTADIENE LIGANDS, COMPLEXES THEREOF WITH COPPER AND USE THEREOF IN CATALYSIS

The present invention relates to a method for preparing phosphine butadiene-type ligands, and their use, particularly as catalytic metal ligands used in the reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds.