132474-22-7Relevant academic research and scientific papers
Synthesis and evaluation of oligodeoxynucleotides containing 3'-O-ethyl- 4'-C-(hydroxymethyl)thymidine: Introduction of a novel class of phosphodiester internucleoside linkages
Dreioe,Wengel
, p. 1939 - 1952 (1994)
3'-O-Ethyl-4'-C-(hydroxymethyl)thymidine (5) was synthesized and converted into the phosphoramidite building block 8. Novel oligodeoxynucleotide analogues containing 4'-C-hydroxymethyl phosphodiester internucleoside linkages were synthesized on an automat
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Vanheusden, Veerle,Munier-Lehmann, Helene,Pochet, Sylvie,Herdewijn, Piet,Van Calenbergh, Serge
, p. 2695 - 2698 (2007/10/03)
A number of 2′- and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′-halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.
