132487-18-4

Upstream product

• 101766-04-5 N-butyryl-4(R)-(methoxycarbonyl)-1,3-thiazolidine-2-thione 
• 122230-35-7 p-nitrobenzyl aminodimethylphosphonoacetate 

Downstream Products

• 132400-16-9 (Dimethoxy-phosphoryl)-[(3R,4R)-3-ethyl-2-oxo-4-(2-oxo-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester 
• 132400-15-8 (Dimethoxy-phosphoryl)-[(2R,3R)-3-ethyl-2-(2-hydroxy-ethyl)-4-oxo-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester 
• 132487-21-9 (5R,6R)-6-Ethyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 122230-27-7 p-Nitrobenzyl α-(dimethylphosphono)-α-[3α-ethyl-4β-[2-[dimethyl-(2,3-dimethylbutan-2-yl)silyloxy]ethyl]-azetidin-2-one-1-yl]acetate 

Relevant academic research and scientific papers

Double cyclization of aminophosphonoacetate derived β-hydroxyacids to bicyclic β-lactams

The carbon framework for carbapenems was constructed by an asymmetric aldol condensation and subsequent direct coupling of the resulting β-hydroxy acid equivalent with an aminophosphonoacetate. Cyclization to the monocyclic β-lactam 20 was followed by oxi