Double cyclization of aminophosphonoacetate derived β-hydroxyacids to bicyclic β-lactams

Article abstract of DOI:10.1016/S0040-4020(01)81463-0

The carbon framework for carbapenems was constructed by an asymmetric aldol condensation and subsequent direct coupling of the resulting β-hydroxy acid equivalent with an aminophosphonoacetate. Cyclization to the monocyclic β-lactam 20 was followed by oxi