132487-40-2

Usage

Uses

Used in Pharmaceutical Industry:
(1S,2R)-(-)-2-aminocyclohex-3-enecarboxylic acid hydrochloride is used as a chiral building block for the synthesis of various drugs and bioactive compounds. Its stereochemically pure form makes it an important tool in asymmetric synthesis and the development of new pharmaceutical agents.
Used in Organic Chemistry Research:
(1S,2R)-(-)-2-aminocyclohex-3-enecarboxylic acid hydrochloride is used as a key intermediate in the synthesis of organic compounds, contributing to the advancement of organic chemistry research.
Used in Production of Atropine and Tropane Alkaloids:
(1S,2R)-(-)-2-aminocyclohex-3-enecarboxylic acid hydrochloride serves as a precursor in the production of atropine and other tropane alkaloids, which have various applications in medicine and pharmaceuticals.

InChI:InChI=1/C7H11NO2.ClH/c8-6-4-2-1-3-5(6)7(9)10;/h2,4-6H,1,3,8H2,(H,9,10);1H/t5-,6+;/m0./s1

Upstream product

• 285560-99-8 (1S,6R)-7-azabicyclo[4.2.0]oct-4-en-8-one 
• 22031-53-4 cis-2-aza-3-oxobicyclo<4.2.0>octane 

Relevant academic research and scientific papers

Stereo- and regiocontrolled syntheses of exomethylenic cyclohexane β-amino acid derivatives

Cyclohexane analogues of the antifungal icofungipen [(1R,2S)-2-amino-4-methylenecy clopentanecarboxylic acid] were selectively synthesized from unsaturated bicyclic β-lactams by transformation of the ring olefinic bond through three different regio- and s

The first direct enzymatic hydrolysis of alicyclic β-amino esters: A route to enantiopure cis and trans β-amino acids

The first direct enzymatic method is reported for the synthesis of cis and trans βamino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic β esters in organic media. High enantioselectivities (E usually > 001) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iP iPr2O at 5°C. The resolved products, obtained in good yields (≥42%), could be easily separated.

Advanced procedure for the enzymatic ring opening of unsaturated alicyclic β-lactams

Enantiopure β-amino acids 1a-4a and β-lactams 1b-4b were prepared simultaneously through the lipolase-catalysed enantioselective ring opening of unsaturated racemic β-lactams (±)-1-(±)-4. High enantioselectivities (E>200) were observed when the reactions