22031-53-4Relevant academic research and scientific papers
Nylon-3 polymers that enable selective culture of endothelial cells
Liu, Runhui,Chen, Xinyu,Gellman, Samuel H.,Masters, Kristyn S.
supporting information, p. 16296 - 16299 (2013/12/04)
Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomat
Hairpin folding behavior of mixed α/β-peptides in aqueous solution
Lengyel, George A.,Frank, Rebecca C.,Horne, W. Seth
supporting information; experimental part, p. 4246 - 4249 (2011/06/21)
The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the α-helix, mimicry of protein β-sheets is less understood. We report
Access to poly-β-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of β-lactams
Zhang, Jihua,Kissounko, Denis A.,Lee, Sarah E.,Gellman, Samuel H.,Stahl, Shannon S.
body text, p. 1589 - 1597 (2009/07/30)
Poly-β-peptides are attractive for biomedical applications because the backbone is similar enough to that of proteins for biocompatibility,but the backbone is sufficiently unnatural that these polymers evade pr oteolytic degradation. Prior investigations
Nylon-3 copolymers that generate cell-adhesive surfaces identified by library screening
Lee, Myung-Ryul,Stahl, Shannon S.,Gellman, Samuel H.,Masters, Kristyn S.
experimental part, p. 16779 - 16789 (2010/03/04)
Polymers in the nylon-3 family contain subunits derived from β-amino acids, which are linked to one another via amide bonds. Thus, the nylon-3 backbone is homologous to the α-amino acid-based backbone of proteins. This molecular-level homology suggests th
Large-scale syntheses of FMOC-protected non-proteogenic amino acids: Useful building blocks for combinatorial libraries
Dener, Jeffrey M.,Fantauzzi, Pascal P.,Kshirsagar, Tushar A.,Kelly, Daphne E.,Wolfe, Aaron B.
, p. 445 - 449 (2013/09/07)
Convenient and reliable large-scale procedures for the protection of various amino acids with N-(9-fluorenylmethoxycarbonyl)oxysuccinimide (FMOC-OSu) are described. Commercially available 4-aminomethylbenzoic acid and trans-4-(aminomethyl)cyclohexanecarbo
Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1
Furet, Pascal,Caravatti, Giorgio,Denholm, Alastair A.,Faessler, Alex,Fretz, Heinz,Garcia-Echeverria, Carlos,Gay, Brigitte,Irving, Ed,Press, Neil J.,Rahuel, Joseph,Schoepfer, Joseph,Walker, Clive V.
, p. 2337 - 2341 (2007/10/03)
Based on X-ray crystal structure information, mono charged phosphinate isosteres of phosphotyrosine have been designed and incorporated in a short inhibitory peptide sequence of the Grb2-SH2 domain. The resulting compounds, by exploiting additional interactions, inhibit binding to the Grb2-SH2 domain as potently as the corresponding doubly charged (phosphonomethyl)phenylalanine analogue. (C) 2000 Elsevier Science Ltd.
STEREOCHEMICAL STUDIES, 144. SATURATED HETEROCYCLES, 151. PREPARATION OF cis AND trans-CYCLOALKANE-CONDENSED PYRIMIDINEDIONES BY AZETIDINONE RING TRANSFORMATION
Stajer, Geza,Szoeke-Molnar, Zsolt,Bernath, Gabor,Sohar, Pal
, p. 1943 - 1950 (2007/10/02)
N-substituted derivatives (3 and 4) obtained from cyclopentane- and cyclohexane-azetidinones (1 and 2) were isomerized with polyphosphoric acid to give cyclopentane-cis- (6) and cyclohexane-trans-condensed (7) 2,4-pyrimidinediones.The structures of the dihydrouracils prepared by the ring transformation were proved by 1H- and 13C-nmr spectroscopy and by comparison with the compounds synthesized from cis- and trans-2-amino-1-cycloalkanecarboxamides (11-13) with 1,1'-carbonyldiimidazole.
