132496-78-7

Basic information

• Product Name: Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate
• Synonyms: Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate
• CAS NO: 132496-78-7
• Molecular Weight: 442.896
• Mol File: 132496-78-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate(132496-78-7)
• EPA Substance Registry System: Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate(132496-78-7)

Safety Data

• Hazardous Substances Data: 132496-78-7(Hazardous Substances Data)

Upstream product

• 20624-87-7 3-chloro-4,5-dimethoxybenzoic acid 
• 132496-77-6 methyl 3,4-dihydroxy-5-chlorobenzoate 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1338708-61-4 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide 
• 132496-79-8 5-Chloro-(3,4-di-p-methoxybenzyloxy)benzylalcohol 

Relevant articles and documents

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection.

Cephalosporin compounds and their use

A cephalosporin compound of the formula (I): wherein X and Y may be the same or different and are a hydrogen or halogen atom; Z is a hydrogen or halogen atom, -CH=CH2, -CH=CH-CH3, -OR1, -SR2 or -CH2W in which R1 and R2 are a lower alkyl group and W is a hydrogen atom or a nucleophilic residue, its pharmaceutically acceptable salt, a process for preparing the same and their antibacterial composition.