1338708-61-4

Basic information

• Product Name: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
• Synonyms: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
• CAS NO: 1338708-61-4
• Molecular Weight: 525.044
• Mol File: 1338708-61-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide(1338708-61-4)
• EPA Substance Registry System: 3-chloro-4,5-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide(1338708-61-4)

Safety Data

• Hazardous Substances Data: 1338708-61-4(Hazardous Substances Data)

Upstream product

• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 132496-78-7 Methyl 5-chloro-3,4-di-p-methoxybenzyloxybenzoate 
• 132496-77-6 methyl 3,4-dihydroxy-5-chlorobenzoate 
• 20624-87-7 3-chloro-4,5-dimethoxybenzoic acid 

Relevant articles and documents

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection.