132533-10-9

Upstream product

• 148802-06-6 3-(4-methylphenyl)but-2-en-1-ol 
• 1268605-50-0 ethyl 3-hydroxy-3-(4-methylphenyl)butanoate 
• 94853-54-0 3-p-Tolyl-2-butenol 
• 130633-06-6 (E)-3-(4-methylphenyl)-but-2-en-1-ol 

Downstream Products

• 132533-22-3 (3R,6R)-3-(4-Methoxy-phenyl)-6-(1-p-tolyl-vinyl)-[1,2,4]trioxane 
• 132533-14-3 3,3-Dimethyl-6-(1-p-tolyl-vinyl)-[1,2,4]trioxane 
• 1381931-66-3 ethyl 8-sec-butyl-2-oxo-6-(6-(1-p-tolylvinyl)-1,2,4-trioxan-3-yl)-2H-chromene-3-carboxylate 
• 1381931-65-2 methyl 8-sec-butyl-2-oxo-6-(6-(1-p-tolylvinyl)-1,2,4-trioxan-3-yl)-2H-chromene-3-carboxylate 
• 1381931-63-0 methyl 8-methyl-2-oxo-6-(6-(1-p-tolylvinyl)-1,2,4-trioxan-3-yl)-2H-chromene-3-carboxylate 
• 1381931-64-1 ethyl 8-methyl-2-oxo-6-(6-(1-p-tolylvinyl)-1,2,4-trioxan-3-yl)-2H-chromene-3-carboxylate 
• 889099-60-9 3-(1-p-tolyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecan-9-ol 
• 132533-18-7 3-(1-p-Tolyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecane 

Relevant academic research and scientific papers

Coumarin-trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds

First synthesis of novel coumarin-trioxane hybrids is reported. The synthesis was achieved via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p-toluenesulfonic acid in good yields and the novel hybrids were evaluated for

Orally active antimalarials: Synthesis and bioevaluation of a new series of steroid-based 1,2,4-trioxanes against multi-drug resistant malaria in mice

A new series of steroid-based 1,2,4-trioxanes 7a-f, 8a-f and 9b-e have been synthesized and evaluated for their antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice by oral route. The biological activity shows a strong depend

SPIRO-1,2,4-TRIOXANES AS ANTIMALARIAL AGENTS

The present invention provides novel spiro trioxane series of general Formula (4). This invention also provides a process for the preparation of novel spiro trioxane series. These novel spiro-trioxane cmpounds useful as anti-malarial agents.

Novel spiro-1,2,4-trioxanes

The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups such as phenyl, 4-biphenyl, 4-c

Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice

Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTIMALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4 wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents pheny

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTI-MALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula (4): wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents ph

Preparation of β-hydroxyhydroperoxides by photooxygenation of allylic alcohols and their elaboration into 1,2,4-trioxanes

Dye-sensitized photooxygenation of 3-aryl-2-butenols 2a-e furnishes 3-aryl-1-hydroxy-but-3-en-2-hydroperoxides 3a-e which condense with aldehydes and ketones to give active antimalarial 1,2,4-trioxanes.