13258-68-9Relevant articles and documents
Asymmetric organocatalytic synthesis of 2,3-allenamides from hydrogen-bond-stabilized enynamides
Ma, Zhi-Gang,Wei, Jie-Lu,Lin, Jun-Bing,Wang, Guan-Jun,Zhou, Jia,Chen, Kai,Fan, Chun-An,Zhang, Shu-Yu
, p. 2468 - 2472 (2019)
Asymmetric catalytic synthesis of 2,3-allenamides from hydrogen-bond-stabilized enynamides in the presence of quinine-based bifunctional squaramide organocatalysts is described. This protocol forms a variety of 2,3-allenamides in high yields and excellent
Base-Controlled Cu-Catalyzed Tandem Cyclization/Alkynylation for the Synthesis of Indolizines
Oh, Kyung Hwan,Kim, Seong Min,Park, Sun Young,Park, Jin Kyoon
supporting information, p. 2204 - 2207 (2016/06/01)
A base-controlled Cu-catalyzed tandem cyclization/alkynylation of propargylic amines provides rapid access to functionalized indolizine derivatives under mild reaction conditions. The reaction first proceeded via a 5-endo-dig aminocupration, followed by a coupling between the copper-bound intermediate and alkynyl bromide, to afford the products in good to excellent yields. The successful tandem reaction is attributed to the unique property of the bases, DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene used).
A Novel Efficient Approach to the Synthesis of 6-Oxo Ethinylestradiol and its 3-Isopropanesulfonate
Weber, Gisela,Schaumann, J.,Carl, Constanze,Schwarz, S.,Leisner, Rosemarie
, p. 223 - 230 (2007/10/02)
Ethinylestradiol (1) was converted into the corresponding 6-oxo derivative 7 by a short and simple procedure involving acetate 10 and ketone 11.Phase transfer catalyzed esterification of compound 7 with propane-2-sulfonyl chloride gave sulfonate 12.