38002-18-5

Usage

Uses

Used in Pharmaceutical Industry:
1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL-6-ONE is used as an active pharmaceutical ingredient for the development of medications targeting hormonal imbalances and related conditions. Its unique structure allows it to interact with the body's hormonal receptors, providing potential therapeutic benefits.
Used in Research and Development:
In the field of research and development, 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL-6-ONE serves as a valuable compound for studying the effects of hormonal interactions and the development of new drugs. Its synthesis and properties can be further explored to create novel therapeutic agents.
Used in Hormonal Regulation:
1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL-6-ONE is used as a hormonal regulator, particularly for conditions related to imbalances in estrogen and progesterone levels. Its ability to mimic the effects of these hormones can help in managing symptoms and providing relief to patients.
Used in Contraceptive Development:
As a derivative of Norethindrone Acetate and Ethynyl Estradiol, 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL-6-ONE holds potential for use in the development of contraceptive products. Its hormonal properties can be utilized to create effective birth control methods.
Used in Treatment of Gynecological Disorders:
1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL-6-ONE is used as a treatment option for various gynecological disorders, such as endometriosis, polycystic ovary syndrome (PCOS), and menstrual irregularities. Its hormonal regulation capabilities can help alleviate symptoms and improve the quality of life for patients suffering from these conditions.

Upstream product

• 68-22-4 norethisterone 
• 1476-34-2 6-oxoestrone 
• 74-86-2 acetylene 
• 51414-87-0 17α-ethinyl-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene-6-one 
• 13258-68-9 ethynylestradiol diacetate 
• 57-63-6 ethinyl estradiol 
• 3434-45-5 6-oxo-3,17β-estradiol diacetate 
• 51414-80-3 C₂₁H₂₆O₄ 
• 571-92-6 6-ketoestradiol 
• 104661-61-2 3,17β-diacetoxy-17α-ethinylestra-1,3,5(10)-trien-6-one 

Downstream Products

• 27521-34-2 17α-ethynylestra-1,3,5(10)-trien-3,6α,17β-triol 
• 56324-28-8 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,6β,17α-triol 

Relevant academic research and scientific papers

Synthesis and crystal structure of a new mestranol acetate

A new mestranol acetate, 17α-ethinyl-17-hydroxy-3-methoxyestra-1,3, 5(10)-triene-6-one-17-acetate, was synthesized by an efficient three-step sequence starting from norethindrone. The structure of the new steroid was characterized by 1H NMR, 13C NMR, MS, IR spectrum and X-ray single crystal diffraction. It crystallizes in the triclinic system, space group P1. The molecules are arranged in a head-to-tail fashion without intra- and intermolecular hydrogen bonding.

Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references

Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of

A Novel Efficient Approach to the Synthesis of 6-Oxo Ethinylestradiol and its 3-Isopropanesulfonate

Ethinylestradiol (1) was converted into the corresponding 6-oxo derivative 7 by a short and simple procedure involving acetate 10 and ketone 11.Phase transfer catalyzed esterification of compound 7 with propane-2-sulfonyl chloride gave sulfonate 12.

OXIDATIONS OF ENONE SYSTEMS IN STEROIDS BY OXIDIZERS WITH REVERSIBLE REDOX POTENTIAL

The oxidation of steroid enones by oxidizers with reversible redox potentials (mostly tetrazolium salts) is described.Products containing an oxo or hydroxy group at the position γ with respect to the oxo of the enone group were isolated in relatively high yields.The results of kinetic studies on the redox processes are reported and a reaction mechanism is proposed.