132584-54-4

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 138165-75-0 N-Boc-L-β-homoleucine 
• 100-39-0 benzyl bromide 
• 142570-65-8 ethyl 2-diethylphosphono-3-phenylpropionate 
• 86834-95-9 3(S)-[(tert-butoxycarbonyl)amino]-5-methylhexanal 

Downstream Products

• 132549-47-4 Boc-L-Leu-Ψ(CH2-CH2)-L-Phe-OH 
• 132549-47-4 Boc-L-Leu-Ψ(CH2-CH2)-D-Phe-OH 
• 132549-45-2 (3S,6R)-3-benzyl 6-isobutyl-piperidin-2-one 
• 132549-46-3 (3R,6R)-3-benzyl 6-isobutyl-piperidin-2-one 
• 132549-49-6 (R)-2-Benzyl-5-tert-butoxycarbonylamino-7-methyl-octanoic acid ethyl ester 

Relevant academic research and scientific papers

'CARBA' peptide bond surrogates: Synthesis of Boc-L-Leu-Ψ(CH2-CH2)-L-Phe-OH and Boc-L-Leu-Ψ(CH2-CH2)-D-Phe-OH through a Horner-Emmons reaction

A synthesis of Boc-L-Leu-Ψ(CH2-CH2)-L-Phe-OH and Boc-L-Leu-Ψ(CH2-CH2)-D-Phe-OH from Boc-βhomo-L-leucinal, through a Horner-Emmons reaction with ethyl 2-(diethylphosphono)-3-phenylpropionate is described. Interme