'CARBA' peptide bond surrogates: Synthesis of Boc-L-Leu-Ψ(CH2-CH2)-L-Phe-OH and Boc-L-Leu-Ψ(CH2-CH2)-D-Phe-OH through a Horner-Emmons reaction

Article abstract of DOI:10.1016/S0040-4039(00)88554-8

A synthesis of Boc-L-Leu-Ψ(CH₂-CH₂)-L-Phe-OH and Boc-L-Leu-Ψ(CH₂-CH₂)-D-Phe-OH from Boc-βhomo-L-leucinal, through a Horner-Emmons reaction with ethyl 2-(diethylphosphono)-3-phenylpropionate is described. Interme