132600-30-7Relevant articles and documents
Electrochemical Cross-Dehydrogenative Coupling between Phenols and β-Dicarbonyl Compounds: Facile Construction of Benzofurans
Ding, Mengning,Shi, Zhuangzhi,Tian, Bailin,Wang, Yandong
supporting information, (2020/03/23)
Preparative electrochemical synthesis is an ideal method for establishing green, sustainable processes. The major benefits of an electro-organic strategy over that of conventional chemical synthesis are the avoidance of reagent waste and mild reaction conditions. Here, an intermolecular cross-dehydrogenative coupling between phenols and β-dicarbonyl compounds has been developed to build various benzofurans under undivided electrolytic conditions. Neither transition metals nor external chemical oxidants are required to facilitate the dehydrogenation and dehydration processes. The key factor in success was the use of nBu4NBF4 as the electrolyte and hexafluoroisopropanol as the solvent, which play key roles in the cyclocondensation step. This electrolysis is scalable and can be used as a key step in drug synthesis. On the basis of several experimental results, the mechanism, particularly of the remarkable anodic oxidation and cyclization process, was illustrated.
ACETALES OF LACTAM AND AMIDE ACIDS. 59. SYNTHESIS OF DERIVATIVES OF BIS(BENZOFURYL-3)KETONES
Mukhanova, T. I.,Alekseeva, L. M.,Granik, V. G.
, p. 739 - 742 (2007/10/02)
The reaction of substituted 3-acetylbenzofurans with dimethylformamide diethylacetal gave the corresponding enaminoketones, which reacted with p-benzoquinone to give bis(benzofuryl-3)ketone derivatives.
