13262-31-2

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(3,4-dihydroquinolin-1(2H)-yl)-3-phenylprop-2-en-1-one is used as a pharmaceutical candidate for its potential anti-cancer, anti-malarial, and anti-inflammatory properties. Quinoline derivatives, including (2E)-1-(3,4-dihydroquinolin-1(2H)-yl)-3-phenylprop-2-en-1-one, have been studied for their ability to target and treat various diseases, making them valuable in drug development and medicinal chemistry.
Used in Scientific Research:
In the scientific community, (2E)-1-(3,4-dihydroquinolin-1(2H)-yl)-3-phenylprop-2-en-1-one serves as a subject of study for understanding the structure-activity relationships of quinoline derivatives. This knowledge can contribute to the advancement of new drug discovery and the optimization of existing therapeutic agents.

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 102-92-1 cinnamoyl chloride 
• 88611-48-7 1-(3,4-dihydroquinolin-1(2H)-yl)prop-2-en-1-one 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1225386-88-8 (E)-1-benzylidene-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-2(4H)-one 
• 1225386-93-5 (Z)-1-benzylidene-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-2(4H)-one 

Relevant academic research and scientific papers

Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones

The catalyst-free electrochemical di- and trifluoromethylation/cyclization of N-substituted acrylamides was realized under external oxidant-free conditions. The strategy provides expedient access to fluoroalkylated oxindoles and 3,4-dihydroquinolin-2(1H)-ones with ample scope and broad functional group tolerance by mild, direct electrolysis of sodium sulfinates in an undivided cell. Detailed mechanistic studies provided strong support for a SET-based reaction manifold.

Rh(i)-Catalyzed regioselective arylcarboxylation of acrylamides with arylboronic acids and CO2

The first Rh(i)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO2 has been developed. A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.

Silver-catalyzed radical tandem cyclization for the synthesis of 3,4-disubstituted dihydroquinolin-2(1 H)-ones

A silver-catalyzed tandem decarboxylative radical addition/cyclization of N-arylcinnamamides with aliphatic carboxylic acids is reported. This method affords a novel and straightforward route to various 3,4-disubstituted dihydroquinolin-2(1H)-ones in aque

Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation

A strategy involving palladium-catalysed aromatic C-H functionalisation/ intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl2MeCN 2 and AgOCOCF3, a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield. The Royal Society of Chemistry.