132623-46-2

Upstream product

• 67-56-1 methanol 
• 873981-45-4 4-chloro-2-(cyanomethyl-amino)-benzoic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 153501-26-9 ethyl 6-chloro-3-hydroxyindole-2-carboxylate 
• 911824-20-9 1-(4-tert-butyl-phenyl)-6-chloro-3-hydroxy-1H-indole-2-carboxylic acid ethyl ester 
• 911823-85-3 1-(4-tert-butyl-phenyl)-6-chloro-3-methoxy-1H-indole-2-carboxylic acid ethyl ester 
• 911827-03-7 1-(4-tert-butyl-phenyl)-6-chloro-3-(3-isopropyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911827-00-4 1-(4-tert-butyl-phenyl)-6-chloro-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 1597613-89-2 (7R,8S,9R,9aS)-methyl 3-chloro-7-(2-ethoxy-2-oxoethyl)-8-nitro-10-oxo-9-phenyl-6,7,8,9,9a,10-hexahydropyrido[1,2-a]indole-9a-carboxylate 
• 1597614-01-1 C₁₇H₂₀ClNO₆ 

Relevant academic research and scientific papers

Oxidative Coupling of 3-Oxindoles with Indoles and Arenes

A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.

Stereogenic: Cis -2-substituted- N -acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation

Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines to cis-2-substituted-N-acetyl-3-hydroxyindolines is reported. Using the homochiral {Ru[TfDPEN](p-cymene)} catalyst with S/C = 400 in a HCO2H/Et3N mixture, up to >99.9% ee and >99:1 dr are obtained with high yields (79-98%). This method provides the first example of preparing enantiomerically pure indolines through asymmetric transfer hydrogenation (ATH).

Organocatalytic enantioselective amination of 2-substituted indolin-3-ones: A strategy for the synthesis of chiral α-hydrazino esters

An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with h

Organocatalytic asymmetric Michael-Michael cascade for the construction of highly functionalized N-fused piperidinoindoline derivatives

Application of indolin-3-one derivatives in a cascade reaction for efficient assembly of complex molecules is a much less explored research area. It is demonstrated that structurally interesting polysubstituted piperidino[1,2-a]indoline compounds containi

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.