153501-26-9

Upstream product

• 188566-29-2 ethyl N-[5-chloro-2-(ethoxycarbonyl)phenyl]glycinate 
• 132623-46-2 4-chloro-2-(methoxycarbonylmethyl-amino)-benzoic acid methyl ester 
• 141-52-6 sodium ethanolate 
• 60064-34-8 2-Carboethoxy-5-chloroaniline 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 

Downstream Products

• 911827-00-4 1-(4-tert-butyl-phenyl)-6-chloro-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911827-03-7 1-(4-tert-butyl-phenyl)-6-chloro-3-(3-isopropyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911823-85-3 1-(4-tert-butyl-phenyl)-6-chloro-3-methoxy-1H-indole-2-carboxylic acid ethyl ester 
• 911824-20-9 1-(4-tert-butyl-phenyl)-6-chloro-3-hydroxy-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

Synthesis, pharmacology and therapeutic potential of 10-methoxypyrazinoindoles, partial agonists at the 5HT2C receptor

A series of new 10-methoxypyrazinoindoles has been prepared and shown to be 5HT2C receptor ligands.The studied compounds 10a-j were found to act as partial agonists at the 5HT2C receptor, binding with high affinity and moderate selectivity versus 5HT1A and 5HT2A receptors, but inducing only a submaximal increase in phosphonoinositol formation.Compound 10j was demonstrated to be active in animal models of obsessive-compulsive disorder, depression and panic anxiety. - Keywords: pyrazinoindole; serotonin; 5HT2C receptor; partial agonist; psychiatric disorder.