1326242-72-1

Basic information

• Product Name: Di-Tert-Butyl 1-(Bicyclo[1.1.1]Pentan-1-Yl)Hydrazine-1,2-Dicarboxylate
• Synonyms: Di-Tert-Butyl 1-(Bicyclo[1.1.1]Pentan-1-Yl)Hydrazine-1,2-Dicarboxylate
• CAS NO: 1326242-72-1
• Molecular Formula: C15H26N2O4
• Molecular Weight: 298.37794
• Mol File: 1326242-72-1.mol

Chemical Properties

• Melting Point: 135 °C (decomp)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 8.94±0.20(Predicted)
• CAS DataBase Reference: Di-Tert-Butyl 1-(Bicyclo[1.1.1]Pentan-1-Yl)Hydrazine-1,2-Dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Di-Tert-Butyl 1-(Bicyclo[1.1.1]Pentan-1-Yl)Hydrazine-1,2-Dicarboxylate(1326242-72-1)
• EPA Substance Registry System: Di-Tert-Butyl 1-(Bicyclo[1.1.1]Pentan-1-Yl)Hydrazine-1,2-Dicarboxylate(1326242-72-1)

Safety Data

• Hazardous Substances Data: 1326242-72-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure allows for the formation of a variety of chemical bonds, facilitating the synthesis of diverse compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is utilized as a key intermediate in the development of pharmaceuticals. Its ability to form stable bonds with other molecules makes it a valuable component in the synthesis of bioactive compounds with potential therapeutic applications.
Used in Material Science:
Di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate also finds applications in material science, where it can be incorporated into the design and synthesis of new materials with specific properties. Its versatility in forming chemical bonds contributes to the development of materials with tailored characteristics for various applications.
Used as a Reagent in Chemical Reactions:
di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is employed as a reagent in various chemical reactions, where its reactivity and stability play a crucial role in facilitating the desired transformations. Its presence can enhance the efficiency and selectivity of reactions, making it a valuable tool in the synthesis of target molecules.

Upstream product

• 98577-44-7 1,1-bis(chloromethyl)-2,2-dibromocyclopropane 
• 311-75-1 bicyclo[1.1.1]pentane 
• 870-50-8 di-tert-butyl (E)-azodicarboxylate 
• 870-50-8 di-tert-butyl-diazodicarboxylate 
• 35634-10-7 [1.1.1]propellane 

Relevant articles and documents

Development of Scalable Routes to 1-Bicyclo[1.1.1]pentylpyrazoles

The application of bicyclo[1.1.1]pentanes (BCPs) as phenyl bioisosteres has garnered significant attention, as these structural motifs can improve the physiochemical profiles of drug candidates. Despite the potential of using 1-bicyclo[1.1.1]pentylpyrazol

MACROCYCLIC COMPOUNDS

The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

FUSED FURANS FOR THE TREATMENT OF HEPATITIS C

The disclosure provides compounds of formula I or II, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. [

SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein G is R1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Scalable synthesis of 1-bicyclo[1.1.1]pentylamine via a hydrohydrazination reaction

The reaction of [1.1.1]propellane with di-tert-butyl azodicarboxylate and phenylsilane in the presence of Mn(dpm)3 to give di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is described. Subsequent deprotection gives 1-bicyclo[1.1.1]pentylhydrazine followed by reduction to give 1-bicyclo[1.1.1]pentylamine. The reported route marks a significant improvement over the previous syntheses of 1-bicyclo[1.1.1] pentylamine in terms of scalability, yield, safety, and cost.