132691-44-2

Basic information

• Product Name: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate
• Synonyms: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate;methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate
• CAS NO: 132691-44-2
• Molecular Weight: 293.363
• Mol File: 132691-44-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate(132691-44-2)
• EPA Substance Registry System: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate(132691-44-2)

Safety Data

• Hazardous Substances Data: 132691-44-2(Hazardous Substances Data)

Upstream product

• 68819-84-1 tert-butyl N-(4-bromobenzyl)carbamate 
• 3959-07-7 4-Bromobenzylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 103565-40-8 4-(Aminomethyl)benzenepropanoic acid methyl ester hydrochloride 

Downstream Products

• 100511-78-2 methyl 3-(4-aminomethylphenyl)propionate 
• 61629-79-6 β-[4-(5-chloro-2-methoxybenzamidomethyl)-phenyl]-propionic acid 
• 191870-75-4 (R,S)-N₅-[(1,1-Dimethylethoxy)carbonyl]-N₂-(diphenylacetyl)-N-[[4-[2-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-phenyl]methyl]-ornithinamide 
• 191870-73-2 3-methyl-5-[2-[4-(aminomethyl)phenyl]ethyl]-1,2,4-oxadiazole-hydrochloride 
• 132691-45-3 3-[4-[(tert.Butyloxycarbonylamino)methyl]phenyl]propionic acid 

Relevant articles and documents

Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity

DNA-methyltransferases (DNMTs) are a class of epigenetic enzymes that catalyze the transfer of a methyl moiety from the methyl donor S-adenosyl-l-methionine onto the C5 position of cytosine in DNA. This process is dysregulated in cancers and leads to the hypermethylation and silencing of tumor suppressor genes. The development of potent and selective inhibitors of DNMTs is of utmost importance for the discovery of new therapies for the treatment of cancer. We report herein the synthesis and DNMT inhibitory activity of 29 analogues derived from NSC 319745. The effect of selected compounds on the methylation level in the MDA-MB-231 human breast cancer cell line was evaluated using a luminometric methylation assay. Molecular docking studies have been conducted to propose a binding mode for this series.

PYRROLIDINE DERIVATIVES AS TRYPTASE INHIBITORS

Compounds of a certain formula 1 in which M, B1, B2, R2, K1 and K2 have the meanings indicated in the description are novel effective tryptase inhibitors.