132696-45-8Relevant articles and documents
Highly enantioselective conjugate addition of dialkylzinc reagents to acyclic nitroalkenes: A catalytic route to β2-amino acids, aldehydes, and alcohols
Duursma, Ate,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 3700 - 3701 (2003)
Using chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition to acyclic nitroalkenes for the first time, we obtained enantioselectivities up to 98%. The use of acyclic substrates with different dialkylzinc reagents provides a catalytic enantio
Impact on hydrogenation catalytic cycle of the R groups Cyclic feature in "r-SMS-Phos"
Zupancic, Borut,Mohar, Barbara,Stephan, Michel
supporting information; experimental part, p. 3022 - 3025 (2010/08/19)
A series of R-SMS-Phos ligands was evaluated in the Rh(I)-catalyzed hydrogenation of a set of olefins showing a marked influence of the cyclic nature and structure of the R groups. Overall, cPen- and Cy-SMS-Phos performed efficiently, while Ph- and Bn-SMS-Phos exhibited slower kinetics and furnished lower ees also compared with C6F5CH2-SMS-Phos. The Rh(I)-(Cy-SMS-Phos) catalyst was screened under mild conditions displaying excellent enantioselectivities and high TOFs. Cases of catalysis under catalyst or substrate control were identified.
New scalable asymmetric aminomethylation reaction for the synthesis of β2-amino acids
Moumne, Roba,Denise, Bernard,Guitot, Karine,Rudler, Henri,Lavielle, Solange,Karoyan, Philippe
, p. 1912 - 1920 (2008/02/06)
β-Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β2-amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O-acetals by Mannich-type iminium electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.