132697-07-5

Basic information

• Product Name: (+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine
• Synonyms: (+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine
• CAS NO: 132697-07-5
• Molecular Weight: 233.354
• Mol File: 132697-07-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine(132697-07-5)
• EPA Substance Registry System: (+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine(132697-07-5)

Safety Data

• Hazardous Substances Data: 132697-07-5(Hazardous Substances Data)

Upstream product

• 951240-64-5 C₁₃H₂₅NO₆SBrP 
• 951240-65-6 C₁₀H₁₈NO₂SBr 
• 951240-66-7 C₁₇H₂₅O₃SN 
• 951240-71-4 C₁₃H₁₇ON 
• 220503-22-0 C₁₄H₁₉ON 
• 951240-61-2 C₉H₁₅NO₃S 
• 951240-62-3 C₉H₁₄NO₃SBr 
• 10365-98-7 3-methoxyphenylboronic acid 
• 149710-65-6 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine 
• 132621-45-5 4-(3-Methoxy-phenyl)-1,4,5-trimethyl-1,2,3,4-tetrahydro-pyridine 
• 149710-64-5 1,2,3,4-Tetrahydro-4-(3-methoxyphenyl)-1,4-dimethylpyridine 
• 73224-22-3 1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 951240-63-4 C₉H₁₆NO₃SBr 

Downstream Products

• 119193-09-8 (+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine 
• 149710-89-4 (+/-)-1-<3-(2-furanyl)propyl>-3(R^*),4(R^*)-dimethyl-4-(3-hydroxyphenyl)piperidine 

Relevant articles and documents

First asymmetrie synthesis of frans-3,4-dimethyl-4-arylpiperidines

The first asymmetric synthesis of the trans-3,4-dimethyl-4-arylpiperidine opioid antagonist scaffold is reported. C-3 stereochemistry was established via CBS reduction and stereoselective anti-SN2′ cuprate displacement of the derived allylic phosphonate. The resultant vinyl bromide was then elaborated to the target compound by Suzuki coupling and frans-selective 4-methylation. Extension of this methodology should allow general enantioselective access to highly substituted piperidine ring systems.

Synthesis and Absolute Configuration of LY255582, a Potent Opioid Antagonist

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