149710-89-4

Basic information

• Product Name: 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
• Synonyms: 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
• CAS NO: 149710-89-4
• Molecular Formula: C20H27 N O2
• Molecular Weight: 313.43
• Mol File: 149710-89-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 450.8°Cat760mmHg
• Flash Point: 226.4°C
• Appearance: /
• Density: 1.058g/cm³
• Vapor Pressure: 9.61E-09mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine(149710-89-4)
• EPA Substance Registry System: 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine(149710-89-4)

Safety Data

• Hazardous Substances Data: 149710-89-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H27NO2/c1-16-15-21(11-4-8-19-9-5-13-23-19)12-10-20(16,2)17-6-3-7-18(22)14-17/h3,5-7,9,13-14,16,22H,4,8,10-12,15H2,1-2H3/t16-,20+/m0/s1

Upstream product

• 76181-74-3 (+/-)-1,3(R^*),4(R^*)-Trimethyl-4-(3-methoxyphenyl)-piperidine 
• 149710-64-5 1,2,3,4-Tetrahydro-4-(3-methoxyphenyl)-1,4-dimethylpyridine 
• 149710-65-6 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine 
• 73224-22-3 1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine 

Relevant articles and documents

Structure-activity relationships of trans-3,4-dimethyl-4-(3- hydroxyphenyl)piperidine antagonists for μ- and κ-opioid receptors

A series of racemic N-substituted trans-3,4-dimethyl-4-(3- hydroxyphenyl)piperidines were evaluated for opioid agonist and antagonist activity at μ and κ receptors. Several highly potent μ and κ antagonists were discovered; however, no compounds with high selectivity for either the μ or κ receptor were identified. Importantly, no derivative was found to have significant opioid agonist activity. Two derivatives were resolved, and the activities of the enantiomers were investigated. Only a limited stereochemical effect on opioid receptor selectivities was observed. The structure-activity relationships described establish the existence of an important lipophilic binding site distal to the nitrogen for both μ and κ receptors and confirm the pure opioid antagonist pharmacophore nature of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine structure.