13271-75-5Relevant articles and documents
An Intramolecular Cycloaddition Approach to the Kauranoid Family of Diterpene Metabolites
Callebaut, Brenda,Hullaert, Jan,Van Hecke, Kristof,Winne, Johan M.
supporting information, p. 310 - 314 (2019/01/10)
Synthetic studies toward the ent-kauranoid family of diterpene natural products are reported. An intramolecular (4 + 3) cycloaddition allows the direct elaboration of diverse natural product frameworks, encompassing a challenging bicyclo[3.2.1]octane core. The established routes comprise only a few synthetic operations (3-5 steps), transforming a range of simple starting materials into the tetracyclic scaffolds that are commonly found in many ent-kaurene metabolites.