60633-91-2

Usage

Uses

Used in Chemical Synthesis:
2-(Bromomethyl)benzaldehyde is used as a key intermediate for the preparation of triiron complexes of PDK, a porphyrin-linked dicarboxylate ligand. This application is significant in the development of new materials and compounds with potential applications in various industries.
Used in Pharmaceutical Industry:
2-(Bromomethyl)benzaldehyde can be utilized as a building block in the synthesis of pharmaceutical compounds, particularly those with potential therapeutic properties. Its unique structure allows for the creation of novel drug candidates that can target specific biological pathways or receptors.
Used in Material Science:
In the field of material science, 2-(Bromomethyl)benzaldehyde can be employed in the development of new materials with unique properties. Its ability to form complexes with metal ions, such as triiron, can lead to the creation of advanced materials with potential applications in various sectors, including electronics, energy, and environmental technologies.

InChI:InChI=1/C8H7BrO/c9-5-7-3-1-2-4-8(7)6-10/h1-4,6H,5H2

Upstream product

• 37803-24-0 o-Diacetoxymethyl-benzylbromid 
• 31675-37-3 2-diacetoxymethyltoluene 
• 529-20-4 2-methylphenyl aldehyde 
• 22115-41-9 2-(bromomethyl)benzonitrile 

Downstream Products

• 138829-05-7 Bis(2-formylbenzyl)sulfide 
• 1218996-93-0 2-((naphthalen-2-yl)methyl)benzaldehyde 
• 1218996-94-1 2-((6-methoxynaphthalen-2-yl)methyl)benzaldehyde 
• 1338438-27-9 2-((2-oxothiazol-3(2H)-yl)methyl)benzaldehyde 
• 408527-91-3 2-((1,3-dioxoisoindolin-2-yl)methyl)benzaldehyde 
• 128174-77-6 2-phenyl-1,2-dihydrophthalazine 
• 1418202-39-7 2-phenyl-1,2-dihydrophthalazine 
• 1418202-40-0 2-(3-methylphenyl)-1,2-dihydrophthalazine 
• 1418202-42-2 2-(2,4-dimethylphenyl)-1,2-dihydrophthalazine 
• 1418202-43-3 2-(3,4-dimethylphenyl)-1,2-dihydrophthalazine 
• 1418202-44-4 2-(4-isopropylphenyl)-1,2-dihydrophthalazine 
• 128174-78-7 2-(p-methoxyphenyl)-1,2-dihydrophthalazine 
• 1418202-45-5 2-(3-chlorophenyl)-1,2-dihydrophthalazine 
• 1418202-46-6 2-(3-fluorophenyl)-1,2-dihydrophthalazine 

Relevant academic research and scientific papers

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions

Synthetic agents that disrupt intracellular protein-protein interactions (PPIs) are highly desirable for elucidating signaling networks and developing new therapeutics. However, designing cell-penetrating large molecules equipped with the many functional

A Highly Fluorinated Chiral Aldehyde for Enantioselective Fluorescent Recognition in a Biphasic System

A 1,1′-bi-2-naphthol (BINOL)-based aldehyde containing four perfluoroalkyl groups has been designed and synthesized. It shows enantioselective fluorescence enhancement at 420 nm when treated with the enantiomers of trans-1,2-diaminocyclohexane in an organ

Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons

A palladium-catalyzed tandem carbonylative lactonization and Diels-Alder cycloaddition reaction between aldehyde-tethered benzylhalides and alkenes has been developed. A range of alkenes and aldehyde-tethered benzylhalides bearing different substituents can be successfully transformed into the corresponding bridged polycyclic compounds in good yields. This strategy provides a unique approach to complex lactone-containing bridged polycyclic compounds.

Compound with PPAR delta agonistic activity, pharmaceutical composition and medical application

The invention discloses a compound with PPAR delta agonistic activity, a pharmaceutical composition and medical application, wherein the structure of the compound is shown as a formula I in the specification. The compound shown in the formula I is a novel

Synthesis of various cyclopropyl methyl bromide and its derivatives from ketones and/or aldehydes and some β-dicarbonyl compounds in the presence of BrCN and Et3N

The ultimate goal in this paper has been developed for the synthesis of structurally various bromomethyl cyclopropane via an α-bromoketone and/or aldehydes with ethyl cyanoacetate or malononitrile and cyanogen bromide (BrCN) in the presence of Et3N to give products in excellent yields within about 3?s. All structures were characterized by IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. The reaction mechanism was discussed.

An Intramolecular Cycloaddition Approach to the Kauranoid Family of Diterpene Metabolites

Synthetic studies toward the ent-kauranoid family of diterpene natural products are reported. An intramolecular (4 + 3) cycloaddition allows the direct elaboration of diverse natural product frameworks, encompassing a challenging bicyclo[3.2.1]octane core. The established routes comprise only a few synthetic operations (3-5 steps), transforming a range of simple starting materials into the tetracyclic scaffolds that are commonly found in many ent-kaurene metabolites.

Fe(III)-Catalyzed Aerobic Intramolecular N-N Coupling of Aliphatic Azides with Amines

An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five- and six-membered semisaturated diazoheterocycles using air as an oxidant is reported, providing an alternative to hydrazine-based methods. Mechanistic studies suggest that a N-radical induced intramolecular homolytic substitution (SH2) is involved in ring closure. The power of this N-N bond-forming method is also demonstrated by using it as the final step in a total synthesis of (-)-newbouldine.

Highly selective construction of medium-sized lactams by palladium-catalyzed intramolecular hydroaminocarbonylation of aminoalkynes

A novel palladium-catalyzed intramolecular hydroaminocarbonylation of aminoalkynes has been developed. This direct and operationally simple protocol provides a rapid and reliable approach to a diverse array of valuable seven-and eight-membered lactams with high chemoselectivity and regioselectivity. The high selectivity might be attributed to rational tuning the electronic nature of the amine moiety and the palladium catalyst which enabled this transformation to proceed in the absence of acidic or any other additives under fairly mild reaction conditions. This method paves the way for the synthesis of medium-sized lactams.

One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction

A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 5, an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes 7 or 1,2-dihydroisoquinolines 9 in

Annulation of o-Quinodimethanes through N-Heterocyclic Carbene Catalysis for the Synthesis of 1-Isochromanones

The activation of 2-(bromomethyl)benzaldehydes using N-heterocyclic carbenes represents a novel approach to the generation of o-quinodimethane (o-QDM) intermediates. Coupling with ketones such as phenylglyoxylates, isatins, or trifluoromethyl ketones via [4 + 2] annulation gives access to functionalized 1-isochromanones.