132715-04-9Relevant articles and documents
8-Hydroxylated Derivatives of Diazabicyclononanes, 2,5-Dioxodiazabicyclononanes and Some Related Esters
Diafi, Lahcen,Couquelet, Jacques,Tronche, Pierre,Gardette, Daniel,Gramain, Jean-Claude
, p. 2181 - 2187 (2007/10/02)
Pharmacological considerations promted the authors to synthesize a series of 8-hydroxylated optically active derivatives of diazabicyclononanes and of their 2,5-dioxo analogs from trans-4-hydroxy-L-proline.Esterification with appropriate anhydrides led to the corresponding esters with 6S,8R configuration.Inversion of configuration at C-8 was performed using Mitsunobu method and led to the diastereoisomeric series of 6S,8S esters.A tentative pharmacological evaluation was carried out in the area of sedative and spasmolytic activities.